干扰素信号通路及其负调控因素的研究进展  

Investigation Advancements of IFN Signal Pathway and Negatively Regulating Factors

作　　者：刘梅[1] 张丽丽[1] 陈明[1] 

机构地区：[1]徐州医学院附属医院感染病科,江苏徐州221002

出　　处：《医学综述》2009年第19期2896-2898,共3页Medical Recapitulate

基　　金：2008年"徐州医学院研究生科技创新计划"项目(11)

摘　　要：干扰素通过与细胞膜上的特异性受体结合,引发级联信号放大过程,将信号传递到胞核内,调控一系列基因表达相应抗病毒蛋白,进而发挥抗病毒作用。干扰素信号通路包括多条途径,其中贾纳斯激酶-信号转导和转录活化因子(JAK-STAT)通路是经典途径。目前证实有信号转导抑制因子(SOCS)、蛋白酪氨酸磷酸酶(PTP)、PIAS 3个负调控因子家族。SOCS同PTP家族中的SHP-1均是JAK-STAT信号转导负反馈圈的重要组成部分;PIAS是一个双向调节系统,在特定细胞因子刺激下,能增减STATs活化的数量。The antiviral effect of Interferon is possibly through binding to specificity receptors on cytoplasmic membrane, initiating cascade process of signal amplification. Signal then migrates to the nucleus where regulation gene express a set of antiviral protein. JAK-STAT signal pathway is the classical one in Interferon signal pathway. The families of negative regulators regulate Interferon signal transduction to inhibit antiviral protein expression. Three negative regulatory factor families have been confirmed：SOCS, PTP and PIAS. Overexpression of SOCS proteins inhibits the JAK-STAT pathway. SOCS proteins and SHP-1 are important elements in a classic negative feedback loop that regulating JAK- STAT signal transduetion. Different from SOCS and SHP-1, PIAS proteins do not act to form a negative feedback loop,but rather may act like a buffer,titrating the amount of activated STATs that is available within particular cells following cytokine stimulation.

关 键 词：干扰素 JAK-STAT信号转导通路 负调控因子 

分 类 号：R512.6[医药卫生—内科学]