小窝及小窝蛋白1在肝再生中的作用  

Caveolin and Caveolin-1 in Liver Regeneration

作　　者：李晓晴[1] 杨仙珊[1] 张晶[1] 

机构地区：[1]首都医科大学附属北京佑安医院人工肝中心,北京100069

出　　处：《医学综述》2009年第19期2915-2917,共3页Medical Recapitulate

摘　　要：生长因子和细胞因子在肝再生过程中发挥着重要作用,小窝蛋白1就是其中之一。小窝蛋白1参与脂质代谢调节、信号转导和物质运输等。小窝蛋白1表达缺陷的小鼠部分肝切除术后肝脏再生能力和存活率降低。小窝蛋白1调节的脂质聚集能促进肝细胞再生过程,在肝细胞损伤后肝细胞的增殖反应机制中发挥着重要作用。Growth factors and cytokines,including caveolin-1,play important roles in the process of liver regeneration.Caveolin-1 involves in the lipid metabolism,signal conduction and material transportation.Caveolin-1-/-mouse exhibited impaired liver regeneration and low survival rate after a partial hepatectomy.The lipid accumulation mediated by caveolin-1 can promote the process of liver regeneration.Caveolin-1 plays a crucial role in the proliferative response occurring in the liver after cellular damage.

关 键 词：小窝 小窝蛋白1 肝再生 

分 类 号：R575[医药卫生—消化系统]