50例白血病SAPO-1/FaS实验结果分析  

THE ANALYSIS OF EXPERIMENT RESULT IN SAPO-1/FAS FOR 50 CASES OF LEUKEMIA

作　　者：金丽华[1] 扬剑国[1] 罗宗彝[1] 

机构地区：[1]海南省人民医院,570311

出　　处：《海南医学》1998年第4期248-249,共2页Hainan Medical Journal

摘　　要：在人外周血中发现一种可溶性FaS分子存在，由于RNA剪接方式不同，造成跨膜区缺失或不完整所致。SAPO－1／FaS与FaS配体（或抗FaS单克隆抗体）有很高的亲和力而起到间接抑制调亡的作用。本实验组50例各类型白血病中淋巴细胞型白血病和慢性粒细胞白血病SAPO－1／FaS明显增高证实FaS的表达和结构上的变化与白血病的发生、发展有着极其重要的关系。这预示了人们将有可能在白血病中通过调控细胞凋亡来达到治疗和预防白血病的目的。A kind of soluble Fas molecule has been found in the peripheral blood. Somedefect or incompleteness of transmembrancearea were caused by the difference of RNAcut-combination way. SApo-1/Fasmatched with Fas (or monoclonal antibody)has a high affinity so that it Iead to the action of indirect inhibition apoptosis In thisexperimental group, 50 cases of varlous typeof Iymphatic Ieukemia and chronic granulocytic Leukemia, SApo-1/Fas increased soobviously that the factors of occurrence anddevelopment in Leukemia with change ofconstruction and expression of Fas were revealed and the important relaton of themwere considered. The experiment will predict a possidbility that the Leukemia may betreated and prevented by regulating apoptosis.

关 键 词：SAPO-1/FAS 细胞凋亡 白血病 实验研究 

分 类 号：R733.7[医药卫生—肿瘤]