复方肿瘤血管生成抑制因子口服液与化疗药物对小鼠S_(180)肉瘤的抑制作用  

Inhibiting effects of using compound oral liquor of the tumor angiogenesis inhibitor and chemotherapeutic drugs together on S 180 sarcoma cells in mice

作　　者：杨保胜[1,2,3] 李永林 向华 夏民 李效阳[1,2,3] 徐存拴 

机构地区：[1]新乡医学院细胞生物学教研室 [2]河南九圣药业集团 [3]河南师范大学生物系

出　　处：《新乡医学院学报》1998年第4期306-311,共6页Journal of Xinxiang Medical University

基　　金：河南省杰出青年基金

摘　　要：目的探讨复方肿瘤血管生成抑制因子口服液（ＣＯＬ－ＴＡＩ）与化疗药物联合对小鼠Ｓ１８０肉瘤的抑制作用。方法小鼠接种Ｓ１８０细胞后，随机分成对照组、ＣＯＬ－ＴＡＩ大剂量组、小剂量组以及各种剂量合用化疗药物实验组，１０ｄ后观察各组小鼠的肿瘤重量并计算抑瘤率。结果ＣＯＬ－ＴＡＩ不仅单独使用可抑制肿瘤生长，抑瘤率为１７．８３％～２６．９１％（Ｐ＜０．０５），而且与化疗药物合用有增强抗癌的作用，ＣＯＬ－ＴＡＩ在体内可明显增强化疗药物的抑瘤效应。单独使用环磷酰胺（ＣＴＸ）、阿霉素（ＡＤＭ）和５－氟尿嘧啶（５－Ｆｕ）时，抑瘤率分别为４１．９１％、３２．７３％和２５．９０％，三者分别与ＣＯＬ－ＴＡＩ合用时，抑瘤率分别为５７．１０％、５５．２８％和３０．２４％。结论ＣＯＬ－ＴＡＩ不仅单独使用具有抑制肿瘤生长的作用，而且与化疗药物合用有明显的增效作用。Objective To research the synergistic effects of the compound oral liquor of the tumor angiogenesis inhibitor(COL-TAI) and chemotherapeutic drugs on inhibiting S 180 sarcoma in mice.Methods After inoculating the S 180 cell, the mice were rendomly divided into control group, the low dose group and the high dose group of COL-TAI,the combination group of COL-TAI and chemotherapeutic drugs, cytoxan(CTX),adriamycin(ADM) and 5-Fu.Beginning on day 1 and ending on day 10, the weight of the tumor was observed, the inhibitory rate was calculated.Results The COL-TAI could inhibit obviously the proliferation of S 180 sarcoma(the inhibitory rate was 17.83%～26.91%),when in combination with COL-TAI and chemotherapeutic drugs, the synergistic effects were also observed, When CTX, ADM and 5-Fu were used alone, the inhibiting rate was 41.91%,32.73% and 25.90%.When they were respectively in combination with COL-TAI,the inhibiting rate were 57.10%, 55.28% and 30.24% in different groups.COL-CAI may inhibit the growth of the S 180 sarcoma in vivo. Conclusion COL-TAI shows obviously enhancing effect of inhibiting growth of tumor when it is combined with chemothempentic drugs. It may be a effectual antitumor drugs when it is used along.

关 键 词：抗肿瘤药物 S180细胞 复方口服液 肿瘤 

分 类 号：R730.58[医药卫生—肿瘤]