吗啡在楔状核伤害感受调制中作用的研究  

INVESTIGATION OF THE MECHANISM OF THE ANTINOCICEPTIVE ROLE OF OPIOIDS IN NUCLEUS CUNEIFORMIS

作　　者：李韶[1] 杜功梁[1] 崔存德 张慧[1] 张自东[1] 

机构地区：[1]武汉同济医科大学

出　　处：《滨州医学院学报》1998年第6期526-529,共4页Journal of Binzhou Medical University

摘　　要：目的：观察中脑楔状核（ＮＣＦ）尾部给予外源性吗啡对延髓中缝大核（ＮＲＭ）和中脑导水管周围灰质（ＰＡＧ）内痛兴奋神经元（ＰＥＮ）的痛放电影响。方法：用玻璃微电极细胞外记录方法，分别在ＮＲＭ和ＰＡＧ内记录ＰＥＮ的单位放电。结果：（１）ＮＣＦ内注入吗啡（３×１０－２ｍｏｌ／Ｌ）能明显抑制ＰＡＧ、ＮＲＭ内ＰＥＮ的痛放电频率；（２）ＮＣＦ内微量注入纳洛酮（２．７４×１０－３ｍｏｌ／Ｌ）能增加ＰＡＧ、ＮＲＭ内ＰＥＮ的痛放电频率；（３）ＮＣＦ内预先注射纳洛酮（５．５×１０－３ｍｏｌ／Ｌ）能部分阻断吗啡对ＰＡＧ、ＮＲＭ内ＰＥＮ痛放电抑制效应。结论：ＮＣＦ内某些神经元与抗伤害性感受有关；Objective:To explore the effect of microinjecting morphine of naloxone into nucleus cuneiformis(NCF) on the frequencies of evoked discharge of pain excitation neurons (PEN) in periaqueductal gray(PAG) or nucleus raphe magnus(NRM).Methods:The extracellular recording method was used to investigate the effect of the antinociceptive role of opioids in NCF.Results:(1)Intra NCF injection of morphine(3×10 -2 mol/L,n=8) could suppress the frequencies of evoked discharge of PEN in PAG or NRM ( P <0 001,0 01,0 05),the maximal inhibitory rate was (77 3±7 5)% and (78 4±7 0)% respectively;(2)Naloxone(2 74×10 -3 mol/L,n=8)injected into NCF could enhance the evoked discharges of PEN in PAG and NRM( P <0 01,0 05),the percentage of change in the frequence of evoked discharge increased by (82 9±4 1)% and (79 5±3 1)% respectively.(3)Both of the above mentioned inhibitory effects of morphine (n=8) could be antagonised by intra NCF preinjection of naloxone (5.5×10 -3 mol/L,n=8)( P <0 001)。Conclusion:Some neurons in NCF might participate in the process to modulate noxious information transmission in CNS.Endogenous opiate might be a neuromodulator or transmitter in the antinociception of NCF.Both of the inhibitions of morphine injected into NCF on the PEN in PAG or NRM may be mediated by opioid receptor.

关 键 词：楔状核 导水管周围灰质 中缝大核 痛调制 吗啡 

分 类 号：R742[医药卫生—神经病学与精神病学]