含铂方案治疗老年非小细胞肺癌的临床观察  

Clinical observation of combination chemotherapy with Cisplatin-based regiment in non-small cell lung cancer

作　　者：马晴[1] 马力[1] 吕慧[1] 

机构地区：[1]天津市医科大学总医院肿瘤科,天津300052

出　　处：《武警医学院学报》2009年第11期950-952,共3页Acta Academiae Medicinae CPAPF

摘　　要：【目的】研究适合老年非小细胞肺癌患者的含铂化疗方案。【方法】选择37例ⅢB-Ⅳ期老年非小细胞肺癌患者,分为TC治疗组(Paclitaxel,紫杉醇联合Carboplatin,卡铂)及GP治疗组(Gemcitabine,吉西他滨联合Cisplatin,顺铂),观察其近期疗效和毒副反应。【结果】TC治疗组和GP治疗组有效率分别为23.5%(4/17)和25%(5/20),P=1,差异无统计学意义。GP治疗组Ⅲ-Ⅳ度恶心呕吐发生率高于TC治疗组的发生率,P=0.000,有统计学意义。两组Ⅲ-Ⅳ度白细胞减少以及肝功能变化无差异,P>0.05。【结论】初步研究结果提示,两者均是治疗晚期非小细胞肺癌的有效方案,TC方案依从性好,适用于老年患者。[Objective] To study which cisplatin - based regiment is suitable for older people with non - small cell lung cancer. [Methods] 37 cases of non - small cell lung cancer patients were treated with TC （PTX ＋ CBP） or GP （GEM ＋ DDP） for evaluating the clinical efficacy and toxicity. [Results] The response rate （RR） in Group TC and Group GP were 23.5%（4/17） and 25% （5/20）, respectively, P = 1. The main toxicity was hematological toxicity, nausea and vomiting. The incidences of Ⅲ-Ⅳ Grade of nausea and vomiting in Group GP were significantly higher than those in Group TC, P = 0.000. [Conclusions] The efficiency is similar in two groups in the treatment of NSCLC, but Group TC has good compliance and it was referred to older people with non-small cell lung cancer.

关 键 词：非小细胞肺癌 吉西他滨 紫杉醇 顺铂 卡铂 

分 类 号：R73-36[医药卫生—肿瘤]