腹型与匀称型青少年肥胖症相关实验指征的比较  

Comparison of obesity.related laboratory results between single abdominal obesity and symmetric obesity in adolescents

作　　者：黄联继[1] 杨锦华[1] 戴朝福[1] 郭树清[1] 

机构地区：[1]广东省韶关学院医学院附属新华医院内儿科,512026

出　　处：《中华临床营养杂志》2009年第2期95-97,共3页Chinese Journal of Clinical Nutrition

摘　　要：目的比较腹型与匀称型青少年单纯性肥胖症的相关实验指征。方法抽样调查两省市青少年学生11460名，选择其中年龄、性别、体重相匹配的31名匀称型重度肥胖者（对照组）及39名腹型肥胖者（研究组）为研究对象，分别检测血压（Bp）、血脂、瘦素（LP）、空腹血糖（FPG）、空腹胰岛素（FINS）、血尿酸（UA），计算胰岛素敏感指标（ISI），并行肝脏B超检查，比较两组间的差异及各因素相关性。结果研究组脂肪肝异常发生率（P=0．04），血甘油三脂（P〈0．001）和载脂蛋白B（P〈0．005），及FINS、LP和UA（P〈0．001）均显著高于对照组；载脂蛋白A（P〈0．005）和IsI（P〈0．001）均显著低于对照组。IJP与FINS呈明显正相关（P〈0．001），与ISI呈明显负相关（P〈0．001）。UA与FINS（P〈0．001）呈明显正相关，与ISI（P〈0．001）呈明显负相关。结论腹型肥胖症青少年发生内分泌及心血管性疾病的危险性高于匀称型肥胖症青少年。Objective To compare the obesity-related laboratory results between single abdominal obesity and symmetric obesity in adolescents. Methods A total of 11 460 young students in two provinces were surveyed. Among them 31 students with symmetric obesity （SO group） and 39 students with single abdominal obesity （SAO group） were enrolled into the analysis. The age, gender, and body weight were matched between two groups. Blood pressure （Bp）, lipids, leptin （LP）, fasting plasma glucose （FPG）, fasting insulin （FINS）, insulin sensi- tivity index （ISI）, and serum uric acid （UA） were measured. Liver ultrasonic imaging was performed. The differ- ences of the laboratory results were compared. Results Compared with the SO group, in the SAO group, the inci- dence of fatty liver （ P = 0. 04 ）, triglyceride （ P 〈 0. 001 ）, apolipoprotein B （ P 〈 0. 005 ） as well as FINS, LP, and UA （ all P 〈 0. 001 ） were significantly higher, while apolipoprotein A was significantly lower （ P 〈 O. 005 ）. LP were positively correlated with FINS （P 〈0. 001 ） and negatively correlated with ISI （P 〈0. 001 ）. FINS were posi- tively correlated with UA （P 〈 0. 001 ） and negatively with ISI （P 〈 O. 001 ）. Conclusion Adolescents with ab- dominal obesity have higher risks of endocrine and cardiovascular diseases than those with symmetrical obesity.

关 键 词：腹型肥胖症 匀称型肥胖症 青少年 瘦素 胰岛素抵抗 尿酸 

分 类 号：R7[医药卫生—临床医学]