肺癌组织中树突状细胞浸润和mP53表达的关系及临床意义  

Relationship between dendritic cell infiltration and mP53 expression in lung cancer and its clinical significance

作　　者：陈宇平 穆传勇[2] 朱晔涵[2] 王一江 宋丽丽 黄建安[2] 

机构地区：[1]吴江市第三人民医院呼吸科,江苏吴江215228 [2]苏州大学附属第一医院呼吸科,江苏苏州215006

出　　处：《江苏大学学报（医学版）》2009年第5期440-442,446,共4页Journal of Jiangsu University：Medicine Edition

基　　金：吴江市科技局立项基金项目(ws2003132)

摘　　要：目的:探讨非小细胞肺癌组织中突变型P53(mutant P53,mP53)表达和树突状细胞(dendritic cell,DC)浸润的关系及临床意义。方法:采用免疫组化染色检测经外科手术切除的60例非小细胞肺癌组织中mP53,CD1α,CD83阳性细胞的表达。结果:肺癌组织中可检测到mP53阳性肿瘤细胞及CD1,αCD83阳性DC的表达;有淋巴结转移组中mP53及CD1α表达率明显高于无淋巴结转移组(P<0.05)。Ⅲ-Ⅳ期组中CD1α阳性DC表达率明显高于Ⅰ-Ⅱ期(P<0.05);mP53阳性肺癌组织中CD83阳性DC表达率明显减少,而CD1α阳性DC表达率明显增加,与mP53阴性组相比差异有统计学意义(P<0.05)。结论:肺癌组织中mP53表达与肺癌组织中浸润树突状细胞的成熟状态密切相关,在肺癌的免疫逃逸和疾病进展过程中起着重要作用。Objective： To explore the relationship between dendritic cell infiltration and mP53 expression in non-small cell lung cancer and its clinical significance.Methods： Immunohistochemical staining was performed to detect expression of CD1α,CD83,mP53 in 60 lung cancer tissues. Results： mP53 positive tumor cells and CD1α,CD83 positive DC can be detected in lung cancer tissues.Expression rate of mP53 positive tumor cells and CD1α positive DC in tumor tissues with lymph node metastases were higher than those without lymph node metastases. CD1α expression in tumor tissues of stage Ill-IV were higher thanthose of stage I - Ⅱ. Expression rate of CD83 in tumor tissues of mP53 positive group were lower than those of negative group while CD1α were higher. All above differences were statistically signifieant （ P 〈 0.05 ）. Conclusion： There is a elose relationship between mP53 and maturation of DC infiltration, mP53 may par- ticipate in tumor progression of disease and play an important role of tumor immune escape.

关 键 词：肺癌 树突状细胞 突变型P53 

分 类 号：R734[医药卫生—肿瘤]