大蒜素改善GJIC功能及抗氧化作用的实验研究  

EXPERIMENTAL RESEARCH ON EFFECT OF ALLITRADI ON IMPROVING GJIC AND ANTI OXIDATION

作　　者：罗阳[1] 吴耕书[1] 张荔彦[1] 杜晶[1] 

机构地区：[1]沈阳医学院生物化学教研室

出　　处：《癌变．畸变．突变》1998年第6期359-361,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：本文从氧自由基、ＧＪＩＣ（细胞间缝隙连接通讯）及ＤＮＡ含量三个不同角度观察了大蒜素可显著减轻氧自由基对细胞的毒害，并能解除苯巴比妥对ＧＪＩＣ的抑制（Ｐ＜００１），提示大蒜素有明显的预防苯巴比妥的动物促癌作用及对抗氧自由基损害的功效。The effect of allitradi on improving GJIC and anti oxidation was investigated by measuring oxygen free radicals, GJIC(gap junction intercellular communication) and DNA. The results showed that allitradi could prevent the cytotoxicity by anti oxidation, relieve the inhibition of phenobarbitone on GJIC(P<0 01). It implys that allitradi could prevent the effect of phenobarbitone on promoting carcinogenesis by increasing the GJIC function, and inhibit the toxic effect of oxygen free radicals on hepatocytes.

关 键 词：抗氧化 大蒜素 苯巴比妥 氧自由基 GJIC 

分 类 号：R965.2[医药卫生—药理学]