新型8-羟基喹啉席夫碱的合成与抑菌活性  

Synthesis and Antibacterial Activity of New Schiff Base Type Derivatives of 8-Hydroxyquinoline

作　　者：颜世娜[1] 张敬[2] 赵斌[1] 李桂芝[3] 范娜[1] 

机构地区：[1]曲阜师范大学化学系 [2]济宁师范专科学校化学系,山东济宁273115 [3]曲阜师范大学生物系,山东曲阜273165

出　　处：《广州化学》2009年第3期22-27,共6页Guangzhou Chemistry

基　　金：山东省曲阜师范大学科研启动基金资助项目(10865501)

摘　　要：以2-甲基-8-羟基喹啉为原料,经羟基保护、甲基氧化、水解后得到2-甲酰基-8-羟基喹啉(L)。L分别与苯胺衍生物缩合得到三种新型喹啉衍生物。经元素分析、红外光谱、紫外光谱、核磁共振谱表征,确定了席夫碱的组成。产物分别与大肠杆菌、产气杆菌、枯草杆菌、变形杆菌、金黄色葡萄球菌进行抑菌活性实验,配体与席夫碱均有较好的抑菌活性。2-methyl-8-hydroxyquinoline was protected the hydroxyl group, followed by oxidation and hydrolyzation to obtain 2-formyl-8-hydroxyquinoline. Three schiff base type derivatives of 8-hydroxyquinoline were synthesized by the reaction of 2-formyl-8-hydroxyquinoline with aniline derivatives. These compounds were identified by the data of EA, IR, UV, 1H NMR and 13C NMR. The antibacterial activity of 2-formyl-8-hydroxyquinoline and schiff base type derivatives of 8-hydroxyquinoline were determined. The results showed that ligand and schiff base type derivatives had good antibacterial activity.

关 键 词：8-羟基喹啉 席夫碱 抑菌活性 

分 类 号：O626.32[理学—有机化学]