中期因子(MK)与脑膜瘤血管生成关系的研究  

Expression of midkine in meningioma and its biological value.

作　　者：李新军[1] 夏祥国[2] 

机构地区：[1]德阳市人民医院脑外科,四川德阳618000 [2]泸州医学院附属医院脑外科,四川泸州646000

出　　处：《四川医学》2009年第9期1373-1375,共3页Sichuan Medical Journal

摘　　要：目的探讨中期因子(MK)蛋白与脑膜瘤中血管生成关系。方法采用S-P免疫组织化学技术,检测52例脑膜瘤组织和10例正常脑膜组织中MK蛋白的表达和微血管密度(MVD),并对二者的关系进行统计学分析。结果52例脑膜瘤组织中,MK蛋白阳性表达率为63.5%,正常脑膜组织中无MK蛋白表达,明显低于肿瘤组织,差异有统计学意义(P=0.001<0.05)。MK蛋白阳性表达程度与MVD呈正相关(rs=0.756,P=0.045<0.05),与肿瘤的血供(rs=0.6518,P=0.041<0.05)密切相关。结论MK蛋白在脑膜瘤组织中有过度表达;MK蛋白的表达与脑膜瘤血管生成相关;MK蛋白有望成为临床上对脑膜瘤生物学行为进行判定的指标。抑制MK的表达,有望为高表达MK的脑膜瘤提供一个新的治疗途径。Objective To investigate the expression of midkine（MK）in meningioma in relation to angiogenesis.Methods The expression of midkine protein levels and microvessel density（MVD）were detected by immunohistochemical technique（S-P）in 52 meningioma tissues and 10 human normal cerebral maters.At the same time,the clinical,screenage.And pathological parameters were statistically analyzed.Results The positive expression rate of midkine in the 52 cases was 63.5%.Otherwise the expression of midkine in human normal cerebral maters were negative.the difference of midkine in meningioma and human normal cerebral maters were significant（P=0.0010.05）.MVD was positively correlated with the expression of midkine（rs=0.756,P=0.0450.05）.Conclusion The expression of midkine in meningioma is significantly correlated to tumors angiogenesis.So may serve as s valuable tumor marker in research meningioma.Then it indicate,inhibit the expression of midkine in meningioma,which would lead to a new ways of treating meningioma.

关 键 词：脑膜瘤 中期因子蛋白(MK) 人原始造血的细胞(CD34) 微血管密度(MVD) 免疫组织化学 

分 类 号：R739.45[医药卫生—肿瘤]