基于三维CT图像重建研制纳米仿生骨基质支架的研究  

Study on fabrication of biomimetic nanoscaled bone matrix by using imaging based three-dimensional construction

作　　者：郭洪刚[1] 刘静[2] 李峰坦[1] 刘海峰[3] 姚芳莲[4] 姚康德[4] 

机构地区：[1]天津医科大学总医院骨科,天津300052 [2]天津市中心妇产科医院,天津300052 [3]新加坡国立大学组织工程研究中心,新加坡117510 [4]天津大学材料学院,天津300072

出　　处：《中国矫形外科杂志》2009年第20期1562-1565,共4页Orthopedic Journal of China

基　　金：天津市卫生局科技基金资助项目(编号:06KZ46)

摘　　要：[目的]分析数字化影像学技术辅助研制生物支架的可行性，评估构筑生物支架的方法。[方法]通过对宿主部位图像扫描，获取该区域解剖数据，对相邻层匹配轮廓间三维表面进行重构来确定支架形貌，以纳米级无机成分为单位，附于壳聚糖及聚己内酯等天然一有机成分，研制纳米复合支架。观察支架形貌、测定支架的孔隙率、亲水性及降解力学特性。[结果]图像三维重构可提高支架外部轮廓的精确度，减少单纯理化制备过程的参数误差，使支架空间三维布局更加合理，孔径200～350μm，孔隙率88．6％±0．43％的支架拥有稳定的降解速率及良好的亲水表面，可达到工程化骨支架的力学要求，能作为骨再生修复的载体框架。[结论]数字化影像学技术研制的支架具有稳定的理化性征，能解决与宿主部位相匹配的难题，具有潜在的研究空间。[Objective] To analyze the feasbility of digitial imaging on scaffold fabrication. [ Method] The morphology of scaffold was obtained by analyzing anatomic data on digital scanning in host area. Fabrication of biomimetic nanoscaled bone matrix was made with combination of chitosan and polycarpolactone and β-TCP. Morphology, pore ratio, degradation and biomechanic characteristics were observed at different periods. [ Result] The fabrication accuracy of outer morphology for scaffold was improved by using three-dimensional construction of imaging, and its physical layout was remarkably arranged. As a satisfactory carrier for bone tissue engineering,pore ratio 88.61% ± 0.43% ranging from 200 - 350 μm of scaffola showed more stable degradation speed and excellent affinity surface. [ Conclusion ] Imaging aided fabrication technique has a good match between host and scaffold, showing vast research potential.

关 键 词：图像 三维重建 纳米 支架 

分 类 号：R318.0[医药卫生—生物医学工程]