Preparation of nucleoside-pyridine hybrids and pyridine attached acylureas from an unexpected uracil ring-opening and pyridine ring-forming sequence  

作　　者：Xue Sen Fan Xia Wang Xin Ying Zhang Dong Feng Ying Ying Qu 

机构地区：[1]School of Chemistry and Environmental Sciences, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang 453007, China

出　　处：《Chinese Chemical Letters》2009年第10期1161-1165,共5页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.20772025);the Program for Science & Technology Innovation Talents in Universities of Henan Province(No.2008HASTIT006);the Natural Science Foundation of Department of Education of Henan Province(No.2008A150013)

摘　　要：Novel pyrimidine nucleoside-3,5-dicyanopyridine hybrids （4） or pyridine attached acylureas （5） were selectively and efficiently prepared from the reaction of 2′-deoxyuddin-5-yl-methylene malononitrile （1）, malononitrile （2） and thiophenol （3） or from an unexpected uracil ring-opening and pyddine ring-forming sequence via the reaction of 1 and 3. It is the first time such a sequence has ever been reported.Novel pyrimidine nucleoside-3,5-dicyanopyridine hybrids （4） or pyridine attached acylureas （5） were selectively and efficiently prepared from the reaction of 2′-deoxyuddin-5-yl-methylene malononitrile （1）, malononitrile （2） and thiophenol （3） or from an unexpected uracil ring-opening and pyddine ring-forming sequence via the reaction of 1 and 3. It is the first time such a sequence has ever been reported.

关 键 词：Pyrimidine nucleoside PYRIDINE Acylureas Ring-opening and -forming reaction 

分 类 号：TQ051.72[化学工程] TS262.5[轻工技术与工程—发酵工程]