Evaluation of lipid peroxidation inhibition and free radical scavenging abilities of 5,6,7-trimethoxy dihydroflavonols  

作　　者：Kc Xin Huang Yu Bing Feng Wei Yao Lei Xiang Yang Feng Wang Hai Bo Li Su Zeng Jing Xu Gong Ming Hui Hu Yu Zhao Xiu Mei Wu Xiao Kun Li Jia Qu 

机构地区：[1]Key Laboratory of Southern Zhejiang TCM R&D, Pharmacy School of Wenzhou Medical College, Wenzhou 325035, China [2]College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China [3]Zhejiang. Chemical Industry Research Institute, Zhejiang Chem-Tech Group Co., Ltd., Hangzhou 310023, China [4]College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, FL 32307, USA

出　　处：《Chinese Chemical Letters》2009年第10期1187-1190,共4页中国化学快报（英文版）

基　　金：supported by Intramural Foundation from Wenzhou Medical College

摘　　要：Four naturally rare 5,6,7-trimethoxy-2,3-cis-dihydroflavonols （3-6） and two 5,6,7-trimethoxy-2,3-trans-dihydroflavonols （7-8） were designed and synthesized. Their antioxidative properties were evaluated by way of examining their scavenging capacities towards DPPH and O2^＊- free radicals, as well as by measuring their inhibitory ability against LPO. Both the 2,3-trans and the 2,3- cis conformers exhibited certain quenching abilities to DPPH and O2^＊- radicals, while most of the synthetic dihydroflavonols demonstrated remarkable inhibition to LPO.Four naturally rare 5,6,7-trimethoxy-2,3-cis-dihydroflavonols （3-6） and two 5,6,7-trimethoxy-2,3-trans-dihydroflavonols （7-8） were designed and synthesized. Their antioxidative properties were evaluated by way of examining their scavenging capacities towards DPPH and O2^＊- free radicals, as well as by measuring their inhibitory ability against LPO. Both the 2,3-trans and the 2,3- cis conformers exhibited certain quenching abilities to DPPH and O2^＊- radicals, while most of the synthetic dihydroflavonols demonstrated remarkable inhibition to LPO.

关 键 词：5 6 7-Trimethoxy-2 3-dihydroflavonols cis-Dihydroflavonols ANTIOXIDANT Lipid peroxidation Free radical scavenger 

分 类 号：TS202.3[轻工技术与工程—食品科学] TN914.4[轻工技术与工程—食品科学与工程]