颌下腺移位术防治鼻咽癌放疗后口干燥症的疗效观察  

The curative effect of glandula angularis transposition to treat xerostomia because of the postradiotherapy of nasopharyngeal carcinoma

作　　者：冼志 刘学奎[2] 盖锡球 叶锦华[1] 黄孝华[1] 张贵阳[1] 

机构地区：[1]东莞市石龙人民医院耳鼻咽喉科,523320 [2]中山大学肿瘤防治中心头颈科,广州510060

出　　处：《国际医药卫生导报》2009年第20期37-39,共3页International Medicine and Health Guidance News

摘　　要：目的观察颌下腺移位术防治鼻咽癌放疗后口干燥症的临床疗效。方法选择符合入选标准的鼻咽癌患者44例,按随机数字表法分成两组,试验组21例,在放疗前将颌下腺移位至颏下区,术后接受常规放疗,放疗时颏下区设置挡块。对照组23例行常规放射治疗。所有病例治疗前均无口干症状且放射剂量相同,放疗后2年进行口干程度问卷调查及分析比较。结果放疗后2年,对照组无口干燥症(G1)0例,轻微干燥症(G2)6例,占26.1%,中度口干燥症(G3)12例,占52.2%,重度口干燥症(G4)5例,占21.7%;试验组无口干燥症(G1)13例,占61.9%,轻微干燥症(G2)6例,占28.6%,中度口干燥症(G3)2例,占9.5%,重度口干燥症(G4)0例;中至重度口干燥症两者之间差异有极显著性(P<0.01)。结论颌下腺移位术能明显减轻鼻咽癌患者的口干燥症状,显著改善鼻咽癌患者放疗后的生存质量,且方法简单,值得推广。Objective To observe clinical curative effect of glandula angularis transposition to treat xerostomia because of the postradiotherapy of nasopharyngeal earcinoma.blothods 44 standard nasopharyngeal carcinoma patients, were divided into two groups according to the form law of random digit, experimental groups with 21 cases, glandula angularis were shifted the district under the chin jaw before radiotherapy, accepted regular radiotherapy while being postoperative, chin district were setted up block piece when the radiotherapy, control group with 23 eases were accepted the regular radiotherapy. It is the same that all cases did not have a mouth that did symptom and radiated the dosage before treatment, carried on the xerostomia questionnaire investigation of the intensity , analyzed and compared after 2 years radiotherapy. Results Radiotherapy after 2 years, in the control group （G1） there were 0 cases of xerostomia, 6 caseses were slight dries （26.1%） in （G2）, 12 easeses were intermediate dries mouth disease （52.2%） in （G3）, there were 5 （21.7%） of severe xerostomia in （G4）; there were no xerostomia in experimental group, there were 13 cases （61.9%） in （G1）, and there were 6 caseses of dries slight（28.6%） in （G2）, 2 caseses of intermediate dries （9.5%） in （G3）, the number of severe xerostomia is 0 in （G4）, Difference has statistics meaning （ X 2= 18.55, P 〈 0.01） between the two from intermediate to severe xerostomia.Conclusions The glandula angularis transposition can obviously lighten the nasopharyngeal carcinoma patients＇ xerostomia, improve the existence quality after patients＇ radiotherapy for nasopharyngeal carcinoma notably, and the method is simple, worth extending.

关 键 词：鼻咽肿瘤 放射治疗 口干燥症 颌下腺移位术 

分 类 号：R739.63[医药卫生—肿瘤]