氟苯尼考-β-环糊精包合物的研制  

Preparation of Inclusion Complex of Florfenicol-β-Cyclodextrin

作　　者：魏海涛[1] 宋敏[1] 李亮华[1] 骆飚[1] 曾振灵[1] 黄显会[1] 

机构地区：[1]华南农业大学兽医学院,广东广州510642

出　　处：《华南农业大学学报》2009年第4期94-97,共4页Journal of South China Agricultural University

基　　金："十一五"国家科技支撑计划(2006BAD31B06);上海市科技兴农重点攻关项目(沪农科攻字(2006)第10-3号)

摘　　要：选择饱和水溶液法制备氟苯尼考-β-环糊精包合物;通过高效液相色谱法(HPLC)测定氟苯尼考-β-环糊精包合物的溶解度和溶出度;采用差热分析法对氟苯尼考-β-环糊精包合物进行物相鉴定.结果表明,氟苯尼考-β-环糊精包合物中氟苯尼考溶解度和溶出度明显增大,氟苯尼考-β-环糊精包合物能显著提高氟苯尼考的水溶性.Florfenicol-β-cyclodextrin was prepared by saturated water solution method;HPLC method was used to determine the solubility and dissolution rate of florfenicol-β-cyclodextrin;The differential thermal analysis（DTA） method was used to describe the status of Florfenicol in inclusion complex. The results showed that the solubility and dissolution rate of florfenicol-β-cyclodextrin were significantly raised compared with Florfenicol itself, florfenicol-β-cyclodextrin can significantly increase its water-solubility.

关 键 词：氟苯尼考 Β-环糊精 包合物 溶解度 溶出度 

分 类 号：S859.5[农业科学—临床兽医学]