乳腺癌中医证型与临床分期及分子标志物关系  

Relationship between Syndrome Type of Traditional Chinese Medicine and Clinical Stage and Molecular Biomarkers in Breast Cancer

作　　者：易维真[1] 汪晓明[1] 张福忠[1] 李华刚[1] 马卉[1] 

机构地区：[1]安徽中医学院第一附属医院普外科,安徽合肥230031

出　　处：《安徽中医学院学报》2009年第5期23-25,共3页Journal of Anhui Traditional Chinese Medical College

摘　　要：目的:探讨乳腺癌中医证型与临床分期及雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)和癌蛋白C-erbB-2关系。方法:选择经病理证实、有完整资料的乳腺癌病例95例,辨证分为肝郁痰凝、冲任失调、正虚毒炽3种中医证型,采用免疫组织化学法对各证型的临床分期及其分子标志物ER、PR、C-erbB-2表达进行分析。结果:95例中,肝郁痰凝型为71例,占74.74%,冲任失调型为9例,占9.47%,正虚毒炽型为15例,占15.79%。Ⅰ期、Ⅱ期乳腺癌中以肝郁痰凝型居多,而Ⅲ期、Ⅳ期中正虚毒炽型所占比例高于肝郁痰凝型和冲任失调型。肝郁痰凝型ER阳性率与正虚毒炽型比较,差异无显著性(P=0.074);肝郁痰凝型ER阳性率与冲任失调型比较,差异有显著性(P=0.022)。各证型PR、C-erbB-2阳性率比较,差异无显著性。结论:乳腺癌早期多为肝郁痰凝型,后期以正虚毒炽型为主。肝郁痰凝型ER表达水平高于冲任失调型,而PR、C-erbB-2的表达与中医证型无明显相关性。Objective. To investigate the relationship between the syndrome type of traditional Chinese medicine （TCM） and clinical stage and the expression of estrogen receptor （ER）, progesterone receptor （PR） and C-erbB-2 oncoprotein in breast cancer. Methods. Ninety-five cases of breast cancer with conformed pathological test and intact data were selected, and differentiated into 3 syndrome types, namely, the stagnation of the liver-qi and phlegm stasis, the disturbance of Chong and Ren channels and the weak- ened body resistance and the heating of pathogens. The expression of ER, PR and C-erbB-2 were analysed using immunohistochemistry method. Results. Of 95 cases, 71 belonged to the syndrome of the stagnation of the liver-qi and phlegm stasis, occupying 74.74%; 9 to the syndrome of the disturbance of Chong and Ren channels, occupying 9.47%o; 15 to the syndrome of the weakened body resistance and the heating of pathogens, occupying 15. 79%. The patients in stage Ⅰ and stage Ⅱ mostly belonged to the syndrome of the stagnation of the liver-qi and phlegm stasis. The proportion of the weakened body resistance and the heating of pathogens in stage Ⅲ and stage Ⅳ was higher than that of the stagnation of the liver-qi and phlegm stasis and the disturbance of Chong and Ren channels. There was no significant difference in the positive rate of ER between the stagnation of the liver-qi and phlegm stasis and the disturbance of Chong and Ren channels （P=0. 074） ; but the positive rate of ER in the stagnation of the liver-qi and phlegm stasis was significantly different from that in the disturbance of Chong and Ren channels （P=0. 022）. There was no significant difference in the positive rate of PR and C-erbB-2 expression among 3 types. Conclusion. Breast cancer in early stage mostly belongs to the syndrome of the stagnation of the liver-qi and phlegm stasis, and in late stage to the weakened body resistance and the heating of pathogens. The expression of ER in the syndrome of the stagnation of the liver-qi a

关 键 词：乳腺癌 辨证分型 雌激素受体 孕激素受体 C-ERBB-2 

分 类 号：R737.9[医药卫生—肿瘤]