格拉司琼不同用药方式对术后镇痛后恶心、呕吐疗效的影响  

Effects of different administrations of granisetron on postoperative nausea and vomiting during postoperative analgesia

作　　者：谭泽龙[1] 陈淼[2] 

机构地区：[1]遵义医学院附属医院麻醉科,贵州遵义563000 [2]遵义医学院附属医院ICU,贵州遵义563000

出　　处：《遵义医学院学报》2009年第4期352-354,共3页Journal of Zunyi Medical University

摘　　要：目的比较格拉司琼不同用药方式对预防术后镇痛后发生恶心、呕吐的疗效差异。方法选择60例ASAⅠ-Ⅱ级择期腹腔镜胆囊切除术(LC)病人,通过随机数字表随机分为四组:镇痛泵联合静脉用药组(A组)、镇痛泵用药组(B组)、静脉用药组(C组)和对照组(D组),每组15例。记录手术结束后的不同时间段(0～1h、1～3h、3～6h、6～12h、12～24h))恶心、呕吐发生例数以及不同时间点(0h、1h、3h、6h、12h、24h)疼痛视觉模拟评分(VAS)。结果不同时间点组内和组间VAS差异无统计学意义(P﹥0.05)。恶心、呕吐发生率在A组和C组间以及B组和D组间差异无统计学意义(P﹥0.05)。而A组和B组间以及C组和D组间差异有统计学意义(P<0.05)。结论术后静脉注射格拉司琼较其他用药方式可明显减少术后镇痛后恶心、呕吐的发生率。Objective To compare the differences in effect of granisetron in different administrations for the prevention on postoperative nausea and vomiting during postoperative analgesia. Methods Sixty Laparoscopic cholecystectomy patients were divided into 4 groups with ASA Ⅰ - Ⅱ. Analgesia pump joint intravenous drug group （group A） .Analgesia pump drug group （group B） ,intravenous drug group （group C） ,control group （group D）,15 cases each.. Analgesic outcome was evaluated by VAS at 0,1 ,3,6,12 and 24h during PCIA ,and nausea and vomiting were recorded at the same time points. Results There were not significant differences of VAS among the 4 groups（P〉 0.05）. There were not significant differences of the rate in the nausea and vomiting between group A and C or group B and D （P 〉 0.05）. There were significant differences of the rate in the nausea and vomiting between group A and B or group C and D （P 〈 0.05）. Conclusions Intravenous injection of granisetron is better than continuous infusion of it in reducing postoperative nausea and vomiting during PCIA.

关 键 词：格拉司琼 用药方式 术后镇痛 恶心 呕吐 

分 类 号：R730.59[医药卫生—肿瘤]