^18F—FDGPET显像与^99Tc^m-MDP全身骨显像诊断肿瘤骨转移价值的比较  

Comparative study of ^18F-FDG PET imaging and ^99Tc^m-MDP whole body bone imaging in detection of bone metastasis

作　　者：闫瑾[1] 杨建伟[1] 李鹏[1] 宋永平[2] 

机构地区：[1]河南省肿瘤医院PET-CT中心,郑州450008 [2]河南省肿瘤医院血液科,郑州450008

出　　处：《肿瘤研究与临床》2009年第10期678-679,682,共3页Cancer Research and Clinic

摘　　要：目的评价^18F-脱氧葡萄糖（FDG）PET肿瘤显像与^99Tc^m-亚甲基二膦酸盐（MDP）全身骨显像诊断肿瘤骨转移价值。方法43例肿瘤患者，其中28例经其他检查或随访证实为骨转移，15例证实无骨转移。2周对患者内行^18F—FDGPET和^99Tc^m-MDP显像，比较分析两种显像结果。结果28例肿瘤骨转移患者中，^18F—FDG PET阳性26例，^99Tc^m-MDP阳性27例，灵敏度分别为92．9％（26／28）、96.4％（27／28），差异无统计学意义（P〉0．05）。15例无骨转移患者中，PET阴性14例，MDP阴性8例，特异度分别为93．3％（14／15）、53．3％（8／15），差异有统计学意义（P〈0．01）。两种方法检测骨转移的准确率分别为93．0％（40／43）、81．4％（35／43），差异有统计学意义（P〈0．01）。结论^18F—FDGPET诊断肿瘤骨转移的灵敏度与^99Tc^m-MDP显像相近，但特异性和准确性均较高。对^99Tc^m-MDP骨显像阴性、单一病灶及可疑骨转移患者，进一步行^18F—FDG PET显像，可起到信息互补、明确诊断的作用。Objective To compare the clinical value of ^18F-FDG PET imaging and ^99Tc^m-MDP whole body bone imaging in detection of bone metastases. Methods 43 patients were undergone ^18F-FDG PET and ^99Tc^m-MDP imaging within 2 weeks. 28 of them were with confirmed bone metastases by other examinations or follow-up and the remaining 15 were confirmed without bone metastases. The results of the 2 different modalities were analyzed. Results Among 28 patients with confirmed bone metastases, PET and MDP accurately diagnosed 26 and 27, respectively. The sensitivity of them were 92.9 %（26/28）, 96.4 %（27/28）, Among the remaining 19 cases without bone metastases, PET and MDP correctly gave 14 and 8 negative results, respectively. The specificity of them were 93.3 %（14/15）, 53.3 %（8/15）, and accuracy of them were 93.0 %（40/43）, 81.4 %（35/43）. The differences between specificities and accuracies of the two methods were significant, while no significant difference between the sensitivities of the two methods. Conclusion For the detection of bone metastases in patients with malignant tumors, ^18F-FDG PET showed a similar sensitivity but better specificity and accuracy compared with ^99Tc^m-MDP bone scan. For patients with suspected bone metastases, negative finding or single hot spot in ^99Tc^m-MDP imaging, ^18F-FDG PET imaging was recommend as a further and complementary assessment of bone metastases.

关 键 词：肿瘤转移 骨骼 氟脱氧萄糖F18 正电子发射断层显像术 99M锝美罗酸盐 

分 类 号：R730.4[医药卫生—肿瘤]