长期氯氮平治疗引发代谢综合征调查  

Investigation of metabolic syndrome in inpatients of chronic schizophrenia with long-term clozapine treatment

作　　者：张六平 易正辉[2] 方贻儒[2] 禹顺英[2] 李文杰[1] 邵勇[1] 

机构地区：[1]上海市黄浦区精神卫生中心,200122 [2]上海交通大学医学院附属精神卫生中心

出　　处：《临床精神医学杂志》2009年第5期337-339,共3页Journal of Clinical Psychiatry

基　　金：上海交通大学医学院2007~2008年度博士创新基金项目(BXJ0837)

摘　　要：目的:了解长期服用氯氮平的慢性精神分裂症患者伴发代谢综合征(MS)的发生率及相关因素。方法:对370例长期服用氯氮平治疗的慢性住院精神分裂症患者测量身高、体质量、腰围和血压,空腹血糖、血总胆固醇、三酰甘油、高密度脂蛋白胆固醇及进行氯氮平血药浓度测定。结果:长期服用氯氮平治疗的慢性住院精神分裂症患者高血糖、高血压、肥胖、血脂异常及MS的发生率分别为33.2%、24.3%、42.4%、54.9%及19.5%,结论:长期服用氯氮平治疗的慢性住院精神分裂症患者伴发代谢综合征的发生率较高。Objective： To investigte the prevalence rate of metabolic syndrome （MS） in inpatients of chronic schizophrenia with clozapine treatment and analyze related factors. Method ：370 inpatients with chro- nic schizophrenia who had received long-term clozapine medication were assigned to receive physical examina- tions including measurement of height, weight, waist circumference and blood pressure, fasting blood glucose, total cholesteml,triglyceride,high density lipopmteins （HDL-C） and plasma concentration of clozapine. Results： The prevalence rate of the hyperglycemia, hypertension, obesity, dyslipidemia and MS among inpatients of chron- ic schizophrenia with elozapine treatment were 33.2 % ,24.3% ,42.4% ,54.9% and 19.5% ,respectively. Conclusion：There is high prevalence rate of metabolie syndrome （MS） in inpatients of chronic sehizophrenia with clozapine treatment.

关 键 词：慢性精神分裂症 氯氮平 代谢综合征 

分 类 号：R749.053[医药卫生—神经病学与精神病学]