非糖尿病肾病维持性血液透析患者胰岛素抵抗、微炎症状态与脂质代谢紊乱的相互关系研究  

THE CORRELATION OF INSULIN RESISTANCE, MICROINFLAMMATORY STATE WITH LIPID METABOLIC DISORDER IN NON-DIABETIC NEPHROPATHY MAINTENANCE HEMODIALYSIS PATIENTS

作　　者：曾瑜[1] 代碧珍[1] 温向琼[2] 王开正[1] 陈明[2] 

机构地区：[1]四川泸州医学院附属医院检验科,泸州646000 [2]四川泸州医学院附属医院肾内科

出　　处：《现代预防医学》2009年第18期3529-3531,共3页Modern Preventive Medicine

摘　　要：[目的]探讨非糖尿病肾病维持性血液透析患者胰岛素抵抗、微炎症状态与脂质代谢紊乱关系。[方法]测定86例维持性血液透析(MHD)患者及20例健康自愿者血脂、空腹胰岛素(FINS)、空腹血糖(FBS)、血C反应蛋白(CRP)及体重指数(BMI)等指标,并计算胰岛素抵抗指数(HOMA-IR)。[结果]MHD患者出现血清甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、HOMA-IRCRP明显升高,高密度脂蛋白胆固醇(HDL-C)明显减低,BMI也轻度降低;其HOMA-IR与TG、LDL-C、CRP、BMI成正相关,与HDL-C成负相关;其CRP与TG、LDL-C、FINS、HOMA-IR成正相关,与HDL-C成负相关。[结论]MHD患者存在胰岛素抵抗和微炎症状态,它们与脂质代谢紊乱密切相关。[Objective] To explore the correlation of microinflammatory state with lipid metabolic disorder in non-diabetic nephropathy maintenance hemodialysis （MHD） patients. [Methods] The lipid profile, fasting insulin （FINS）, fasting blood sugar （FBS）, serum C-reactive protein （CRP）, body mass index （BMI） were measured in 86 MHD patients and 20 normal controls.Insulin resistance was evaluated using homeostasis model assessment -insulin resistance index （HOMA-IR） . [Results] The serum serum triglyceride （TG） , low density lipoprotein cholesterol （LDL-C） , HOMA-IR, CRP in MHD group were higher significantly than those in control group （P﹤0.05-0.01） and high density lipoprotein cholesterol （HDL-C）, BMI in MHD group were lower significantly than those in control group （P﹤0.05-0.01）. There were positively correlation between HOMA-IR and TG, LDL-C, CRP, BMI and legative correlation between HOMA-IR and LDL-C. There were positively correlation between CRP and TG, LDL -C, FINS, HOMA -IR, BMI and legative correlation between CRP and LDL-C. [Conclusion] There were microinflammatory state and insulin resistance in non-diabetic nephropathy maintenance hemodialysis patients, which were closely correlated with lipid metabolic disorder.

关 键 词：维持性血液透析 脂质代谢 胰岛素抵抗 C反应蛋白质 

分 类 号：R781.64[医药卫生—口腔医学]