Sigma B在单核细胞增生李斯特菌耐受环境压力胁迫中的作用  

Contribution of Sigma B to environmental stress tolerance in Listeria monocytogenes-A review

作　　者：张强[1] 冯莹颖[1] 周青春[1] 罗勤[1] 张晓莉[1] 秦龙娟[1] 

机构地区：[1]华中师范大学生命科学学院遗传调控与整合生物学湖北省重点实验室,武汉430079

出　　处：《微生物学报》2009年第10期1282-1288,共7页Acta Microbiologica Sinica

基　　金：国家自然科学基金(30500025);教育部留学回国人员科研启动基金;教育部211重点学科项目~~

摘　　要：Sigma B(σB)因子在单核细胞增生李斯特菌(Listeria monocytogenes)的压力应答和毒力调控中起着重要的作用。研究发现单核细胞增生李斯特菌的致病力与耐受环境条件的胁迫息息相关。在压力存在的情况下能启动一些基因的表达,以增强细菌对环境的耐受性,这些基因包括与耐受渗透压、酸碱性环境、氧化、极端温度和宿主体内胆碱等环境压力相关的基因。本文综述了σB因子在上述几种环境压力胁迫中的作用,为深入了解该菌的生理特征、探讨食品的最佳生产和保藏条件、防止细菌的感染等方面提供新的理论依据。The alternative sigma factor Sigma B plays important roles in both virulence and stress tolerance in Listeria monocytogenes.It is now clear that there is a strong link between the virulence potential of Listeria monocytogenes and its ability to tolerate stress.Several studies have identified genes that play important roles in stress tolerance and virulence.For example,genes involved in osmotic stress tolerance,acid and alkaline tolerance,oxidative stress tolerance,extreme temperature tolerance,and bile salt tolerance have all been implicated in the virulence of L. monocytogenes. We reviewed the role of SigmaB in several environmental stress conditions to understand the physical character of this microorganism, to discuss the best preservation conditions of food, and to prevent bacterial infection.

关 键 词：单核细胞增生李斯特菌 SIGMA B因子 环境压力胁迫 

分 类 号：R155.5[医药卫生—营养与食品卫生学]