垂体瘤转化基因和C-myc基因在多发性骨髓瘤中表达的研究  

Expression of Pituitary Tumor Transforming Gene and C-myc Gene in Patients with Multiple Myeloma

作　　者：李大启[1] 陈萍[1] 邵建华[1] 董学斌[1] 常亚丽[1] 赵红玉[1] 周亚伟[1] 

机构地区：[1]山东大学附属济南市中心医院血液科,山东济南250013

出　　处：《中国实验血液学杂志》2009年第5期1238-1241,共4页Journal of Experimental Hematology

摘　　要：本研究探讨垂体瘤转化基因(pituitary tumor transforming gene,PTTG)和c-myc基因在多发性骨髓瘤(multiple myeloma,MM)患者中的表达并分析它们与MM发生的关系。采用RT-PCR方法检测33例MM患者及10例正常人骨髓单个核细胞(bone marrow mononuclear cell,BMMNC)中PTTG和c-myc基因的表达。结果表明:MM患者PTTG和c-myc基因的表达明显高于正常对照组(p<0.05)。PTTG基因与c-myc基因的表达呈正相关(r=0.801,p<0.05)。结论:PTTG和c-myc基因的过度表达与MM的发生发展有关。The study was purposed to explore the expressions of pituitary tumor transforming gene and c-myc gene in patients with multiple myeloma （ MM ） and its relationship with pathogenesis of MM. Expressions of pituitary tumor transforming gene and c-myc gene mRNA in BMMNC from 33 patients with MM and 10 normal controls were detected by reverse transcriptase-polymerase chain reation （RT-PCR） . The results showed that the expressions of pituitary tumor transforming gene and c-myc gene mRNA were significantly higher in MM patients those in normal controls（p 〈 0.05 ）. The expression of pituitary tumor transforming gene mRNA was significantly correlated with the expression of c-mye gene （ r = 0. 801, p 〈 0.05 ）. In conclusion, the overexpressions of pituitary tumor transforming gene and c-myc gene may be related to the pathogenesis and progression of MM.

关 键 词：垂体瘤转化基因 c—myc基因 多发性骨髓瘤 

分 类 号：R733.3[医药卫生—肿瘤]