白介素-1受体拮抗剂基因多态性与散发性帕金森病的关系  

Genetic Polymorphism of Interleukin-1 Receptor Antagonist and Sporadic Parkinson's Disease

作　　者：肖颂华[1] 刘军[1] 段朝晖[2] 沈庆煜[1] 邢诒刚[1] 彭英[1] 陶恩祥[1] 

机构地区：[1]中山大学附属第二医院神经科,广州510120 [2]中山大学附属第二医院检验科,广州510120

出　　处：《热带医学杂志》2009年第9期985-987,共3页Journal of Tropical Medicine

基　　金：广东省科技计划项目(No.2006B36004007);广州市科技计划项目(No.2006Z3-E0411);广东省自然科学基金(No.8151008901000035)

摘　　要：目的探讨白介素-1受体拮抗剂(IL-1RA)基因多态性与帕金森病(PD)的关系。方法本实验用PCR-片段长度多态性分析法检测了89例中国散发性帕金森病病人和67例正常对照的白介素-1受体拮抗剂基因多态性。结果与对照组相比,PD组中IL-1RA基因VNTR多态性的A2等位基因有增加的趋势,但两者差异无统计学意义(P>0.05)。帕金森病合并痴呆组(PDD组)中IL-1RA基因A2等位基因频率较非痴呆组(PDND组)有显著性增加(P<0.05),而且在PDD组中,IL-1RA基因A2/A2纯合子和A1/A2杂合子基因型频率较PDND组有显著性增加(P<0.05)。结论IL-1RA基因多态性可能与我国人散发性帕金森病的发病无关,而与帕金森病并发痴呆发病过程中有关。Objective To investigate the association between interleukin- 1 receptor antagonist （IL- 1RA） genetic polymorphism and sporadic Parkinson＇s disease （PD）. Methods IL-1RA genetic polymorphism in 89 patients with sporadic PD and 67 healthy control subjects was analyzed with the polymerase chain reaction restriction fragment length polymorphism （PCR-RFLP）. Results Compared with the control subjects, the frequency of the IL-1RA A2 polymorphism in PD patients was increased, but the different was not significant （P〉0.05）. Compared with the non- dementia （PDND） group, the allelic frequency of the IL-1RA A2 in the dementia （PDD） group was significantly higher （P〈0.05）. The frequency of A2/A2 and A1/A2 was also significantly increased in the PDD group （P〈0.05）. Conclusion IL-1RA genetic polymorphism is related to the pathogenesis of PDND, but not the sporadic PD.

关 键 词：帕金森病 痴呆 白介素-1 多态性 

分 类 号：R742.5[医药卫生—神经病学与精神病学]