腮腺导管龙胆紫灌注实验研究  

Experimental study of parotid gland injected with gentian violet

作　　者：张刚[1] 张祖燕[1] 邹兆菊[1] 吴奇光[1] 

机构地区：[1]北京医科大学口腔医学院

出　　处：《中华口腔医学杂志》1998年第6期338-340,共3页Chinese Journal of Stomatology

摘　　要：目的晚期慢性阻塞性腮腺炎是临床较难治疗的一种疾病。为了解龙胆紫灌注对于腮腺及全身其它组织的影响。方法对６只狗的１２侧腮腺各灌注５ｍｌ龙胆紫，于灌注后３０、６０、１２０分钟、２１天、９个月分别观察腮腺、心、肝、肾等组织的改变，分析灌注对于机体的局部和整体影响。结果腮腺灌注后３天内局部有明显的水肿，一般一周以后基本消退。２１天左右腺体开始明显变化，９个月左右腺体明显萎缩，结缔组织逐渐代替腺体。结论龙胆紫灌注腮腺后逐渐导致腮腺组织被纤维结缔组织所代替，这一过程对于心、肝、肾等组织无明显损害。Objective The Gentian Violet was used for treating the chronic parotitis since 1960's, but the dosage and the histologic changes of the tissues were undefined until now. We try to study the histologic changes of the salivary glands, heart, liver and kidneys after large volume of gentian violet was injected into the parotid gland through the duct.Methods 5 ml of Gentian Violet was injected to each side of 6 dogs. The macropathologic and histologic examination of the salivary glands, heart, liver and kidneys were performed at 30 min, 60 min, 120 min, 21 days and 9 months separately after the perfusion. Results Local swelling was obvious in two or three days after infusion and subsided in one week in most of the dogs. Degeneration of the gland took place after 20 days. After 9 months, the parotid gland tissues were replaced by the connective tissues. On the other hand, no histologic change was observed in heart, liver and kidney in the investigation.Conclusion The Gentian Violet can cause degeneration of the parotid gland including the duct and replaced by connective tissues later. There is no obvious changes were noted in other organs.

关 键 词：腮腺炎 动物实验 龙胆紫 药物疗法 灌注 

分 类 号：R781.720.5[医药卫生—口腔医学]