p53基因与原发性肝癌临床特征的关系  

The Relationship Between p53 Gene and Clinical Characteristics of Primary Hepatic Carcinoma

作　　者：庞春[1] 韩风[1] 

机构地区：[1]河南省肿瘤医院肝胆胰外科,河南郑州450003

出　　处：《肿瘤基础与临床》2009年第4期294-296,共3页journal of basic and clinical oncology

摘　　要：目的探讨p53基因在原发性肝细胞癌(hepatocellular carcinoma,HCC)组织中的表达及其与临床特征的关系。方法应用免疫组化(PV-9000二步法)检测50例HCC组织、30例癌旁组织和10例正常肝组织中p53的表达。结果HCC组织中p53表达阳性率为42.0%(21/50)。HCC组织中p53的阳性表达率高于癌旁组织及正常肝组织(P<0.05)。p53基因的表达与肿瘤转移相关(P<0.05)。结论p53的突变可能在HCC的发生和发展中起重要作用。Objective To investgate the expressions of p53 in primary hepatocellular carcinoma（PHC） and to analyze its correlation with clinical characteristics.Methods The expressions of p53 were evaluated using immunohistochemistry in 50 HCC tissues,30 paracarcinoma tissues and 10 normal liver tissues.Results The positive rate of p53 in HCC was 42.0%（21/50）.The positive rate of p53 in HCC was significantly higher than that of paracarcinoma tissue and normal liver tissues（P〈0.05）.p53 expression were related to metastasis of HCC（P〈0.05）.Conclusion Mutation of p53 may play a crucial roles in the origin and development of HCC.

关 键 词：原发性肝细胞癌 P53 免疫组织化学 

分 类 号：R730.2[医药卫生—肿瘤] R735.7[医药卫生—临床医学]