同步放化疗治疗中晚期食管癌的疗效观察  

Concurrent Chemoradiation Treatment for Local Advanced Esophageal Cancer

作　　者：麦茂[1] 梁文勇[1] 周素珠[1] 黄国富[1] 张慕娟[1] 

机构地区：[1]开平市中心医院肿瘤科,广东开平529300

出　　处：《肿瘤基础与临床》2009年第4期336-338,共3页journal of basic and clinical oncology

摘　　要：目的观察放疗联合DF方案同步化疗治疗中晚期食管癌的疗效。方法放疗联合DF方案(DDP+5-Fu)同步化疗综合治疗中晚期食管癌80例,单纯放射治疗中晚期食管癌76例。结果放化组和单放组的近期疗效总有效率分别为76.3%和59.2%,1、2、3年生存率分别为70.0%、51.3%、38.8%和51.3%、32.9%、23.7%,放化组明显优于单放组(P<0.05)。同期放化组的毒副反应高于单放组,经对症处理后患者能耐受,不影响治疗的进行。结论同期放化疗优于单纯放射治疗,可明显提高中晚期食管癌的疗效。Objective To evaluate the effect of concurrent chemoradiation with DF regimen for local advanced esophageal cancer.Methods 156 cases with local advanced esophageal cancer were divided into two groups： 80 patients treated with radiotherapy plus concurrent chemotherapy with DF regimen（R＋C group）;76 patients treated with radiotherapy alone（R group）.Results The overall response rates（CR＋PR） were 76.3 % in the R＋C group and 59.2 % in the R group,the short-term result of concurrent chemoradiation was better than that of radiotherapy alone（P〈0.05）.The 1,2,3 year survival rates were 70.0%,51.3%,38.8% in the R＋C group and 51.3%,32.9%,23.7% in the R group,respectively.The survival rates in the R＋C group were much better than those in the R group（P〈0.05）.The R＋C group had more obvious side-effect than the R group,but the patients could be tolerated.Conclusion Radiotherapy plus concurrent chemotherapy with DF regimen for local advanced esophageal cancer is more effective than radiotherapy alone.

关 键 词：食管癌 放射治疗 同步化疗 

分 类 号：R735.1[医药卫生—肿瘤]