杏香兔耳风化学成分的分离与鉴定  

Isolation and identification of chemical constituents from the whole plant of Ainsliaea fragrans

作　　者：陈明华[1] 冯锋[1] 柳文媛[2] 王丹[1] 张洁[1] 刘富垒[1] 

机构地区：[1]中国药科大学中药学院,江苏南京210009 [2]中国药科大学药学院,江苏南京210009

出　　处：《沈阳药科大学学报》2009年第10期803-806,共4页Journal of Shenyang Pharmaceutical University

摘　　要：目的研究杏香兔耳风(Ainsliaea fragransChamp.)的化学成分,为活性测试及制定质量标准提供依据。方法利用多种色谱方法进行分离纯化,并根据理化性质和波谱数据确定化合物结构。结果分离并鉴定了9个化合物,其中1个倍半萜:(-)-clovane-2β,9α-diol(1);2个三萜:降香萜醇乙酸酯(bauerenyl acetate,2)、熊果酸(ursolic acid,3);1个寡肽:橙黄胡椒酰胺乙酸酯(aurantiamideacetate,4);5个有机酸类化合物:丁香酸(syringic acid,5)、香草酸(vanillic acid,6)、琥珀酸(succin-ic acid,7)、辛二酸(octanedioic acid,8)、二十六酸(hexacosanic acid,9)。结论上述化合物均为首次从兔儿风属植物中分离得到。Objective To study the chemical constituents of the whole plant of Ainsliaea fragrans Champ. Methods Chemical constituents were isolated by various column chromatographic techniques and their structures were elucidated by spectroscopic methods. Results Nine compounds were isolated from the EtOAc fraction of this plant and were elucidated as （ - ） -clovane-2β, 9α-diol （ 1 ）, bauerenyl acetate （ 2 ）, ursolic acid （3）, aurantiamide acetate （4）, syringic acid （ 5 ）, vanillic acid （ 6 ）, succinic acid （ 7 ）, octanedioic acid （ 8 ）, hexacosanic acid（9）, respectively. Conclusions All compounds are isolated from genus Ainsliaea for the first time.

关 键 词：杏香兔耳风 化学成分 倍半萜 结构鉴定 

分 类 号：R914[医药卫生—药物化学] R284[医药卫生—药学]