认知行为疗法对精神分裂症患者事件相关电位P300的影响  

Effects of cognitive behavioral therapy on the P300 of event - related potential with schizophrenia patients

作　　者：朱性霞[1] 王超[1] 马建东[1] 孙敏[1] 冯砚国[1] 

机构地区：[1]新乡医学院第二附属医院,453002

出　　处：《中国实用医刊》2009年第21期18-19,共2页Chinese Journal of Practical Medicine

摘　　要：目的探讨认知行为疗法对精神分裂症患者事件相关电位P300的影响。方法将112例首发精神分裂症住院患者随机分成两组，研究组实施认知行为疗法，对照组采用单纯药物治疗。采用事件相关电位P300于治疗前和治疗后2个月时进行认知功能评定。结果两组在治疗前事件相关电位P300各项指标差异无统计学意义（P〉0．05），治疗后两组事件相关电位成分中N2、P3波潜伏期较治疗前缩短，P3波幅增高，而研究组改变更为明显，两组差异有统计学意义（P〈0．01）。结论通过认知行为疗法对精神分裂症患者事件相关电位P300的影响，证实其更有助于患者的认知功能康复。Objective To explore the effects of cognitive behavioral therapy on the P300 of event - related potential （ERP） with schizophrenia patients. Methods One hundred and twelve inpatients of schizophrenia were randomly divided into two groups, Cognitive behavioral therapy plus drug was applied to the study group and drug treatment was applied to the control group, Cognition assessment by P300 of ERP were used for the two groups before treatment and two months after treat- ment. Results There were no significant difference between in the indexes of ERP of the two groups before treatment（ P 〉 0.05 ）. After treatment,the latency of N2 ,P3 of ERP and the amplitude of P3 were shorter and higher than before treatment, but the study group changed more obviously, there were significant differences in the two groups （ P 〈 0.01 ）. Conclusions Through the effect of P300 of ERP with cognitive behavioral therapy on schizophrenia patients, It proved that the cognitive behavioral therapy can help to improve its cognition.

关 键 词：认知行为疗法 精神分裂症 事件相关电位P300 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]