角膜干细胞对大鼠角膜碱烧伤后的保护性作用  

Protection of corneal stem cells against the alkali burn rat cornea

作　　者：李双农[1] 于秉丽[1] 谢斌[1] 

机构地区：[1]山西医科大学第一临床医学院眼科

出　　处：《山西医科大学学报》1998年第4期305-307,共3页Journal of Shanxi Medical University

摘　　要：探讨角膜干细胞对角膜烧伤后的保护性作用。分别对大鼠角膜不同区域进行碱烧烧灼，造成不同程度的角膜干细胞损害，连续观察五周。结果：缘部干细胞完全破坏者，角膜以新生血管化愈合，而保留全部或部分干细胞者，角膜无新生血管化。提示角膜干细胞对碱烧伤后阻止角膜的新生血管化，并重建角膜表面的完整性具有重要意义，可能与产生某些抗新生血管因子有关。Objective: To investigate the protection of corneal stem cells against the corneas of alkali burn Methods: The different areas of rat corneas were burned with alkali,causing different damage of corneal stem cells Observation was performed for 5 weeks Results: The corneas whose stem calls were totally destroyed were healed with neovascularization While,the corneas whose stem cells were partially or totally preserved were no vessels Conclusion: The result suggests that corneal stem cells played an important role in preventing the corneal neovascularization and reconstructing the integrity of corneal after alkali burns It may be related to creating some angioinhibitors

关 键 词：角膜烧伤 眼损伤 碱烧伤 角膜干细胞 

分 类 号：R779.13[医药卫生—眼科]