初次小梁切除术并用5-氟尿嘧啶的长期观察  

5-Fluorouracil in initial trabeculectomy

作　　者：王春芳[1] 成霄黎[1] 程凌云[1] 李金龙[1] 

机构地区：[1]山西医科大学第一临床医院眼科

出　　处：《山西医科大学学报》1998年第4期368-369,共2页Journal of Shanxi Medical University

摘　　要：目的评价初次小梁切除术后结膜下注射５－氟尿嘧啶的作用与安全性。方法原发性闭角型青光眼接受初次小梁切除术１６例，作为治疗组于术后第一天开始接受结膜下５－Ｆｕ注射，每次５ｍｇ，共１０次。对照组１６例未接受结膜下注射。结果术前眼内压两组间差异无显著性。出院时眼内压治疗组１６０±０８９ｋＰａ，对照组２５３±１３０ｋＰａ（Ｐ＜００５）。最后一次随访治疗组眼内压（２７３±１００）ｋＰａ，对照组眼内压（３４７±１０３）ｋＰａ（Ｐ＜００５）。功能滤过泡形成率，治疗组７５％，对照组３７５％（Ｐ＜００５）。并发症两组间无差异。结论：５－Ｆｕ可提高初次小梁切除术的成功率，降低术后眼内压水平。Objective: To evaluate the safety and benefit of 5-fluorouracil(5-Fu) subconjunctival injections after initial trabeculectomy.Methods: Sixteen patients with primary narrow angle glaucoma were prospectively assigned to the 5-Fu group on the first postoperative day. Patients in this group received ten 5 mg injections during 2 weeks after surgery.Sixteen patients in the control group received no injection.Results: Preoperative intraocular pressure (IOP) was similar in the 5-Fu and control groups.At the discharge IOP of 5-Fu group was (1.60±0.89) kPa,and of control group(2.53±1.30) kPa (P<0.05).At the last follow-up,IOP of 5-Fu group was(2.73±1.00) kPa,and of control group(3.47±1.03) kPa (P<0.05).The rate of functioning bleb in 5-Fu group was 75%,and in control group 37.5%(P<0.05).The complications were similar in both groups.Conclusions: Adjunctive 5-Fu increases the rate of success of initial trabeculectomy, decreases the level of postoperative IOP, and does not induce obvious complications.

关 键 词：青光眼 氟尿嘧啶 小梁切开术 

分 类 号：R775.205[医药卫生—眼科] R779.6[医药卫生—临床医学]