参与伤害性反应的代谢型谷氨酸受体及信号转导机制  

Metabotropic glutamate receptors involved in nociception and their signaling transductions

作　　者：王云[1] 岳云[1] 吴安石[1] 

机构地区：[1]首都医科大学附属北京朝阳医院麻醉科,100020

出　　处：《国际麻醉学与复苏杂志》2009年第5期473-475,共3页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金资助（30801073）

摘　　要：代谢型谷氨酸受体（metabotropic glutamate receptors，mGluRs）是一类与G蛋白耦联的谷氨酸受体，在外周和脊髓参与伤害性信号的处理，并通过不同的细胞内信号转导机制，调节各种激酶、受体和离子通道的磷酸化以及转录因子的激活，是治疗疼痛的重要靶位。Metabotropic glutamate receptors represent a family of G protein-coupled receptors. They are involved in the nociceptive process at the peripheral and central levels and rigger different signaling transduction pathways, which may further activate a variety of kinases, receptors, ion channels and transcription factors. As such, metabotropic glutamate receptors are potential drug targets for pain relief.

关 键 词：代谢型谷氨酸受体 伤害性反应 信号转导 

分 类 号：R362[医药卫生—病理学]