出血性脑卒中术后高血压危象若干血管活性物质变化研究的机制探讨  

The Research of the Changes of Some Vasoactivators in Hypertensive Crisis After Hemorrhagic Stroke Operation

作　　者：孙宁玲[1] 栾文忠[1] 王智[1] 王鸿懿[1] 李彤妹[1] 

机构地区：[1]北京医科大学人民医院心内科

出　　处：《中国循环杂志》1998年第6期337-339,共3页Chinese Circulation Journal

摘　　要：目的：分析血管活性物质在高血压出血性脑卒中术后高血压危象中的作用。方法：将２２例高血压脑出血患者分为高血压出血性脑卒中术后高血压危象组（Ａ组）９例，高血压出血性脑卒中术后无高血压危象组（Ｂ组）１３例。以同期非出血性脑卒中的颅脑手术患者作为对照组（Ｃ组）９例，分别测定几种血管活性物质含量或活性。结果：①Ａ组患者内皮素、凝血烷Ｂ２（血栓素Ｂ２，ＴＸＢ２）、前列环素（ＰＧＩ２）和去甲肾上腺素的含量及ＴＸＢ２／ＰＧＩ２明显高于Ｂ、Ｃ组患者。②Ａ组患者去甲肾上腺素术后明显高于术前，Ｐ＜００１。结论：ＴＸＢ２／ＰＧＩ２值增加以及内皮素。Objective:To analysize the role of vasoactivators in the post surgical hypertensive crisis patients with hypertensive hemorrhagic stroke. Method:Nine patients complicated with hypertensive crisis after hypertensive intracerebral hemorrhagic operation were group A.The other 13 patients without hypertensive crisis were group B,and other 9 patients without hypertension,intracerebral hemorrhage or post operative hypertensive crisis acted as controls (group C).Some vasoactivators were measured before and after operation in the three groups of patients respectively. Results:①The plasma levels of endothelin 1,thromboxane B 2(TXB 2),prostaglandin I 2 (PGI 2) and norepinephrine were much higher in group A than that of group B and C.②The plasma level of norepinephrine after operation was significantly higher than that before operation in group A, p <0 01. Conclusion:The increasing of the TXB 2/PGI 2 ratio and the plasma levels of endothelin 1 and norepinephrine play roles in the post operative hypertensive crisis.

关 键 词：高血压性脑出血 高血压危象 中风 血管活性物质 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R743.2[医药卫生—临床医学]