p16蛋白在喉鳞癌的表达及临床意义  

Expression of p16 Protein in Laryngeal Carcinoma And Its Clinic Significance

作　　者：沈帆[1] 施作霖[1] 张锟生[1] 江淑萍[1] 

机构地区：[1]福建省立医院

出　　处：《福建医科大学学报》1998年第4期355-357,共3页Journal of Fujian Medical University

基　　金：福建省卫生厅青年基金

摘　　要：目的研究肿瘤抑制基因ｐ１６蛋白的表达与喉癌临床病理的关系。方法应用免疫组化技术ＳＰ法结合高压锅抗原修复对３６例喉鳞癌ｐ１６蛋白的表达进行比较，观察ｐ１６蛋白的表达情况。应用χ２检验及精确概率法分析ｐ１６蛋白表达与鳞癌分级、浸润深度及转移的相关性。结果ｐ１６蛋白在喉鳞癌中的表达率为６３．８９％（２３／３６）；其中，高分化鳞癌的表达率为１００％（６／６）；中分化鳞癌为６６．６７％（１２／１８）；低分化鳞癌为４１．６７％（５／１２），显著低于高中分化组，差异有显著性（Ｐ＜０．０５）。结论ｐ１６蛋白的表达与喉鳞癌的分期、浸润深度及转移密切相关，与病人年龄无关。Objective\ To evaluate the p16 protein expression in laryngeal squamous carcinoma and its clinical and pathologic significance \ Methods\ Immunohistochemistry method was employed to detect the expression of p16 protein in 36 cases of laryngeal carcinoma.\ Results\ The positive rate of p16 in patient of Ⅰ and Ⅱ stages was 81 82%(18/22),which was far higher than that of Ⅲ and Ⅳ stages \ The positive rate of poorly differentiated carcinoma was 41 67%(5/12),which was lower than that of well differentiated carcinoma \ These results indicated that the expression of p16 genes is closely related with the malignancy of larynx carcinoma \ Conclusion\ The expression of p16 genes is associated with the staging,depth of invasion and metastasis of the laryngeal carcinoma

关 键 词：喉肿瘤 P16蛋白 免疫组织化学 

分 类 号：R739.65[医药卫生—肿瘤]