胃癌患者血清VEGF水平测定及临床意义分析  

The Determination of Serum VEGF and Clinical Significance in Patients with Stomach Carcinoma

作　　者：尹惠卿[1] 段昱[1] 徐莉娟[1] 

机构地区：[1]河南省郑州大学第一附属医院检验科,450052

出　　处：《中华全科医学》2009年第11期1171-1172,共2页Chinese Journal of General Practice

摘　　要：目的检测胃癌患者血清血管内皮生长因子(vascular endothelial growth factor,VEGF)表达水平并探讨其临床意义。方法采用酶联免疫吸附技术检测52例胃癌患者及27名健康人血清VEGF水平。结果胃癌患者血清VEGF水平[(293.32±164.35)ng/L]明显高于对照组[(116.26±47.15)ng/L](P<0.05);血清VEGF水平与肿瘤大小、临床分期等有关,与年龄、性别、组织分化程度等因素无关。结论VEGF在胃癌发生、发展过程中起重要作用,检测血清VEGF水平对胃癌的诊断、治疗判断有重要意义。Objective To investigate the clinical significance of serum vascular endothelial growth factor（VEGF） in patients with stomach carcinoma. Methods The levels of serum VEGF in 52 patients with stomach carcinoma and 27 healthy control were measured by ELISA Method. Results The levels of serum VEGF in patients with stomach carcinoma was （293.32 ± 164.35） ng/L and （ 116.26 ± 47.15 ） ng/L in control group, and there was significant difference （ P 〈 0.05 ）. The expression of serum VEGF level was associated with clinical stage of stomach carcinoma, but not with the sex, age of the patients. Conclusion VEGF had important role in the occurring and development of stomach carcinoma. The level of serum VEGF assay can be used to predict the prognosis of stomach carcinoma.

关 键 词：血管内皮生长因子 胃癌 血清 

分 类 号：R735.2[医药卫生—肿瘤] R349.51[医药卫生—临床医学]