食管癌p53过量表达的临床意义  

The Clinical Implication of p53 Overexpression in Esophageal Carcinoma

作　　者：陈志坚[1] 李淳[1] 郑明章[1] 郑瑞明[1] 李德锐[1] 

机构地区：[1]汕头大学医学院肿瘤医院 [2]汕头大学医学院病理教研室

出　　处：《实用癌症杂志》1998年第1期13-15,共3页The Practical Journal of Cancer

摘　　要：为了解ｐ５３过量表达和食管癌临床特点的关系，以及对放射敏感性和预后的影响。作者收集１９８９年４月至１９９３年１２月保存完好、经福尔马林固定、石蜡包埋的放疗前食管癌病理标本６４例，采用免疫组化ＡＢＣ法检测食管癌中ｐ５３的表达情况。对比分析ｐ５３蛋白表达和病灶长度、淋巴结转移、死亡原因、近期疗效和生存率的关系。结果：全组有５７．８％（３７／６４）的肿瘤呈ｐ５３蛋白阳性反应，ｐ５３过量表达和食管癌病灶长度、锁骨上淋巴结转移、近期疗效和生存情况无关，因远处转移死亡者的ｐ５３蛋白阳性率高于局部复发者（Ｐ＜０．０５）。作者认为ｐ５３的过量表达不能作为单独的预后指标用来判断食管癌单纯放疗后的近、远期疗效。Sixtyfour formalin fixed, paraffin embedded specimens of esophageal carcinoma, which underwent radiotherapy alone between December 1989 and April 1993, were analyzed immunohistochemically (ABC assay) to detect the overexpression of p53. The relationship between p53 immunoreactivity and length of lesions, metastases of supraclavicular lymph node, cause of death, radiosensitivity and survival rate was analyzed. Asaresult, nuclear immunoreactivivty for p53 protein was detectable in 37 of 64 tumors (57.8%). There was no correlation between expression of p53 and length of lesions, supraclavicular lymph node metastases, radiosensitivity and survival. The positive rate of p53 was significantly higher in those who died of distant metastases than in those who died of local relapse (P<0.05). The authors concluded that Overexpression of p53 is not an independent prognostic factor for predicting the tumor response to radiotherapy and the survival following radiotherapy in esophageal carcinoma.

关 键 词：食管肿瘤 P53蛋白 放射疗法 预后 

分 类 号：R735.105[医药卫生—肿瘤]