顺铂或卡铂加氟脲嘧啶对中晚期鼻咽癌诱导化疗的疗效对比  

The Effect of Neoadjuvant Chemotherapy on Middle and Advanced NPC by 5Fu plus DDP or CBP

作　　者：戈伟[1] 程晶[1] 徐洁[1] 周云峰[1] 

机构地区：[1]湖北医科大学附属第二医院

出　　处：《实用癌症杂志》1998年第1期54-56,共3页The Practical Journal of Cancer

摘　　要：为比较两种铂类药物单疗程治疗鼻咽癌的临床疗效及毒副作用，作者于１９９６年３月～１０月，将３４例有颈淋巴结转移的中晚期鼻咽癌患者分为两组（每组各１７例）分别采用ＣＢＰ３００ｍｇ／ｍ２，第１天，５－Ｆｕ１０００ｍｇ／ｍ２，第１～５天或ＤＤＰ１００ｍｇ／ｍ２，第１天５－Ｆｕ１０００ｍｇ／ｍ２，第１～５天两种化疗方案进行放疗前单疗程诱导化疗。ＣＢＰ组ＣＲ＋ＰＲ（ＯＲ）为５２．９４％，ＤＤＰ组为６４．７１％，Ｐ＞０．０５，无显著性差异。两组ＷＢＣ值多在第３周最低，第４周回升。ＣＢＰ＋５－Ｆｕ组ＷＢＣ均值从第１周起均较ＤＤＰ＋５－Ｆｕ组低，按ＷＨＯ毒性与分级标准，两组ＷＢＣ值下降分级比较，３＋４度者，ＣＢＰ＋５－Ｆｕ组４７．０６％（８／１７），ＤＤＰ＋５－Ｆｕ组１１．７６％（２／１７），Ｐ＜０．０５，有显著性差异。本组资料提示ＣＢＰ与ＤＤＰ对中晚期ＮＰＣ诱导化疗疗效相近，ＣＢＰ不需水化，可在门诊执行，两组对ＷＢＣ的抑制均在第３周最重。To compare the effect of 5Fu plus DDP with 5Fu plus CBP as neoadjuvant chemotherapy in patients with middle and advanced NPC, a clinical trial was performed from Mar. 1996 to Oct 1996. 34 cases of NPC with lymphonodus metastasis were divided into two groups, group A (17 cases) received DDP 100 mg/m2 (on day 1) plus 5Fu 1 000 mg/m2 (on day 1～5),group B (17 cases) received CBP 300 mg/m2(on day 1) plus same dosage of 5Fu. The effects were evaluated at the fourth week. OR (CR+PR) was 64.71% in group A, 52.94% in group B. No significant difference was found (P>0.05). The data showed that CBP and DDP plus 5Fu have similar theraputic effect as neoadjuvant chemotherapy on NPC and because there is no need of accompaning hydrotherapy. CBP could be more suitable for outpatients.

关 键 词：鼻咽肿瘤 药物疗法 顺铂 卡铂 氟脲嘧啶 

分 类 号：R739.630.5[医药卫生—肿瘤]