uPA、uPAR和PAI-1在恶性卵巢上皮性肿瘤中的表达及临床意义  

Expression of uPA、uPAR and PAI-1 in epithelial ovarian tumor and clinical effect

作　　者：许天敏[1] 崔满华[1] 林杨[1] 王晓丽 

机构地区：[1]吉林大学第二医院妇产科,吉林长春130041 [2]抚松县第二人民医院

出　　处：《中国实验诊断学》2009年第10期1371-1372,共2页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省科学技术厅基金项目(20050410-1;200705203;20080134);长春市科技局项目(06GG88);吉林大学种子基金项目

摘　　要：目的检测72例恶性卵巢上皮性肿瘤中uPA、uPAR和PAI-1的表达情况以探讨三种基因对恶性卵巢上皮性肿瘤的早期诊断及预后判断的意义。方法采用免疫组织化学方法检测uPA、uPAR和PAI-1在恶性卵巢上皮性肿瘤中的表达及其与组织学分类,临床分期,腹水,淋巴结转移预后的关系。结果恶性卵巢上皮性肿瘤在uPA、uPAR和PAI-1的表达阳性率分别73.61%、83.56%、65.75%与卵巢瘤组和正常组之间比较差异有显著性(P<0.05)在晚期卵巢癌,腹水细胞阳性,有淋巴结转移组中uPA、uPAR和PAI-1的表达阳性率显著增高组间比较差异有显著性(P<0.01)。而其表达率与组织学类型无关(P>0.05)。结论uPA、uPAR和PAI-1多个基因表达提示恶性卵巢上皮性肿瘤预后差,uPA、uPAR和PAI-1的多个基因表达的预后判断明显优于其中某个单基因的表达监测,并有望成为今后上皮性卵巢癌生物靶向治疗的新靶点。Objective To investigate the expression of uPA,uPAR,PAI-1in 72 cases of epithelial ovarian tumor were studied in early diagnosis and prognosis.Methods p53,bcl-2 and c-erbB-2 expression were examined immunohistochemically in 72 cases.Results Positive immunostaining for uPA,uPAR,PAI-1were 73.61%,83.56%and 65.75% That were significantly higher than that in negative patients.Positive immunostaining for uPA,uPAR,PAI-1were observed more higher in lated stage of disease,patients with positive ascitic cytology and patients with lymphnode involvement（P〈0.05）.Conclusion The polygene overexpression significantly indicated that epithelial ovarian tumor.determination of overexpression of uPA,uPAR,PAI-1simultaneously was superior to that of one in evaluating the prognosis of uPA,uPAR,PAI-1.

关 键 词：卵巢上皮性肿瘤 基因表达 预后 

分 类 号：R737.31[医药卫生—肿瘤]