p300/CBP及其相关因子PCAF与转录调控  

p300/CBP and p300/CBP-associated Factor with Transcriptional Regulation

作　　者：林娟玉[1] 黄翔[1] 韩爱东[1] 

机构地区：[1]厦门大学生命科学学院,厦门361005

出　　处：《中国生物化学与分子生物学报》2009年第10期877-882,共6页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金专项基金项目(No.30840027)~~

摘　　要：p300/CBP及其相关因子PCAF具有乙酰转移酶活性,能通过乙酰化组蛋白和非组蛋白的方式参与基因的转录调控.同时,它们也能介导多种转录因子.与大多数典型的转录辅激活子相同,它们能在转录因子和基本转录复合物之间起到桥梁作用.p300/CBP与细胞周期调控、细胞凋亡以及癌症的发生等过程之间有着直接的联系.本文概括介绍了p300/CBP与PCAF的基本特性,并简要介绍它们与其它蛋白之间的相互作用,特别是E1A的最新研究进展.p300/CBP and p300/CBP-associated factor （PCAF） exert an intrinsic histone acetyltransferase （HAT） activity. Histones and nonhistone proteins were acetylated to regulate transcriptions of specific sets of genes and interact with various transcription factors. Like the most classical transcriptional coactivators, p300/ CBP and PCAF can also bridge the transcriptional factors to the basal transcriptional complex to maintain the appropriate levels of gene activities during various physiological processes, such as cell cycle, apoptosis and carcinogenesis. The review focuses on the basic characteristics of p300/CBP and PCAF, and the specific interactions with their protein partners in tumor progression, such as E1A, Rb and p53 are also discussed.

关 键 词：P300/CBP PCAF 组蛋白修饰 组蛋白乙酰化酶 转录调控 

分 类 号：Q78[生物学—分子生物学]