JDP2与胰腺癌侵袭及转移的相关性  

Relationship of JDP2 with invasion and metastasis of pancreatic cancer

作　　者：汪海洋[1] 许元鸿[1] 郭克建[1] 

机构地区：[1]中国医科大学附属第一医院普通外科教研室胃肠胰外科,辽宁省沈阳市110001

出　　处：《世界华人消化杂志》2009年第24期2522-2525,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨JDP2蛋白在胰腺癌组织中的表达及其与胰腺癌临床病理特征的关系.方法:利用Western blot检测36例胰腺癌手术切除标本与对应的癌旁胰腺组织中JDP2蛋白的表达.用Log-rank检验分析JDP2蛋白表达与预后的关系.结果:JDP2在胰腺癌中的表达与对应癌旁胰腺组织相比显著下降(0.287±0.052vs0.517±0.172,P<0.05).JDP2在胰腺癌中的表达与肿瘤大小、病理分级、肿瘤累及范围、淋巴结转移、远处转移和临床分期有明显差异(P<0.05),胰腺癌中JDP2的表达水平下降时,术后生存时间明显缩短(P<0.01).结论:JDP2可能与胰腺癌的增殖、侵袭、转移及预后密切相关.AIM： To investigate the expression and the clinical pathological significance of JDP2 protein in pancreatic cancer. METHODS： The expression of JDP2 protein in 36 pancreatic cancer tissues and matched non- cancerous adjacent tissues were detected by Western blot. The association between the ex- pression of JDP2 protein and the prognosis of patients were analyzed by Log-rank test. RESULTS： The expression of JDP2 protein sig- nificantly decreased in pancreatic cancer com- pared with the matched non-cancerous adjacent tissues （0.287 ＋ 0.052 vs 0.517 ＋ 0.172, P 〈 0.05）. The expression of JDP2 protein was closely as- sociated with tumor size, histological type, inva- sion degree, lymph node metastasis, distant me- tastasis and clinical stage （P 〈 0.05）. The survival time of the patients with low JDP2 expression significantly shortened （P 〈 0.01）.CONCLUSION： JDP2 may be closely associated with the proliferation, invasion, metastasis and prognosis of pancreatic cancer.

关 键 词：Jun二聚化蛋白2 胰腺癌 蛋白印迹法 

分 类 号：R735.9[医药卫生—肿瘤]