Toll样受体3与肿瘤免疫  

Toll-like receptor 3 and tumor immunity

作　　者：陈茜圆[1] 夏靖燕[2] 徐峰[1] 

机构地区：[1]浙江大学医学院附属第二医院呼吸科浙江大学呼吸疾病研究所,杭州310009 [2]浙江大学医学院附属第二医院放疗科浙江大学呼吸疾病研究所,杭州310009

出　　处：《国际呼吸杂志》2009年第20期1242-1245,共4页International Journal of Respiration

基　　金：浙江省医药卫生优秀青年科技人才专项基金（2008QN016）

摘　　要：Toll样受体3（TLR3）是参与天然免疫的一类重要分子，是病毒双链RNA的模式识别受体。TLR3表达于免疫细胞和某些非免疫细胞如皮肤角质化细胞、纤维母细胞和肺上皮细胞等，近年来发现人肿瘤组织中也有TLR3表达。TLR3配体双链RNA能直接激活自然杀伤细胞，增强抗原特异性CD8＋T细胞应答，促进树突状细胞的抗原呈递激活。双链RNA也能通过激活多条信号转导途径，直接诱导肿瘤细胞凋亡。TLR3激动剂作为免疫佐剂已应用到某些肿瘤的辅助性免疫治疗。TLR3在肿瘤免疫中的作用及其相关分子机制值得进一步深入研究。Toll-like receptor 3 （TI.R3） is the critical component of the innate immune system that serves to identify viral double stranded RNA（dsRNA）. TLR3 is expressed in immune cells and some nonimmune cells, such as keratinocytes, fibroblast and pulmonary epithelial cells. Recently, it has been reported that TLR3 is expressed in some tumor cell lines. TLR3 ligand dsRNA can directly activate natural killer cells,enhance antigen-specific CD8＋ T cell responses,and promote antigen presentation by dendritic cells. They can also induce apoptosis of tumor cells via activating multiple signal transduction pathways. TLR3 agonists,as immunoadjuvant,have been applied for adjuvant immunotherapy of some tumors. Further studied should be conducted on the effect of TLR3 in tumor immunity and its relative molecular mechanism.

关 键 词：TOLL样受体3 双链RNA 肿瘤免疫 凋亡 信号转导 

分 类 号：R730.3[医药卫生—肿瘤]