消化系统恶性肿瘤血浆D-二聚体与癌胚抗原水平变化的临床意义  

The Evaluation of Plasma D-dimer Levels on Carcinoma State of Digestive System

作　　者：李晓凤[1] 张美云[1] 刘爱勇[1] 王云华[1] 

机构地区：[1]包头市肿瘤医院内二科,内蒙古包头014030

出　　处：《内蒙古医学杂志》2009年第9期1029-1031,共3页Inner Mongolia Medical Journal

基　　金：包头市卫生基金立项课题(2006G2009-15)

摘　　要：目的:通过对消化系统恶性肿瘤患者血浆中D-二聚体测定与血清癌胚抗原做对比,探讨其变化水平在临床判断病情和评估预后中的价值。方法:使用酶联免疫吸附双抗体夹心法原理定量测定90例消化道恶性肿瘤患者血浆D-二聚体(D-Dimer)水平,并选取50名健康人作为对照组,消化系统恶性肿瘤患者同时测定血清癌胚抗原水平。结果:与健康对照组相比,消化道恶性肿瘤组,血浆D-dimer水平明显升高(P<0.01)。在胃癌无转移、淋巴结转移、远处脏器转移3组患者之间,血CEA浓度差异无统计学意义(P>0.05)。而3组患者的血浆D-二聚体浓度差异有统计学意义(P<0.05)。消化道恶性肿瘤转移与无转移组之间CEA及D-dimer比较,均有显著差异。结论:D-二聚体可作为消化系统恶性肿瘤患者病情评估的指标之一。Objective. To study plasma D - dimer （ D - Di） value in evaluating carcinoma state in digestive system. Methods： The concentration of plasma D- Di and serum careinoembryonie antigen（CEA）was determined in 90 eases with carcinoma of digestive system and 50 normal control The correlation was analysed between the concentration of blood D - Di or CEA and the state of the patients with carcinoma of digestive system. Results. Compared with the control group, the concentration of plasma D - Di in the patients with carcinoma was higher significantly than that in control group（P 〈 0.01 ）. The concentration of serum CEA had no difference between patients with or without gastric cancer metastasis. But the concentration of plasma D- Di in patients with gastric cancer metastasis was higher than that in patients without gastric cancer metastasis（P 〈 0. 05）. The concentration of plasma D- Di and serum CEA in the patients with colonic carcinoma metastasis was higher than that in patients without colonic carcinoma metastasis（P〈 0.01）. Conclusion; D- Di is one of the indexes to evaluate the state of the patients with carcinoma of digestive system.

关 键 词：消化系统恶性肿瘤 D-二聚体 癌胚抗原 

分 类 号：R734[医药卫生—肿瘤]