一氧化氮供体型化合物的抗肿瘤作用研究进展  

Advances in Research on Anti-tumor Effect of Nitric Oxide Donor Compounds

作　　者：陈颖[1] 季晖[1] 赖宜生[2] 

机构地区：[1]中国药科大学药理学教研室,江苏南京210009 [2]中国药科大学新药研究中心,江苏南京210009

出　　处：《药学进展》2009年第10期438-445,共8页Progress in Pharmaceutical Sciences

摘　　要：综述一氧化氮供体抗肿瘤作用机制的实验研究新进展,分类介绍一氧化氮供体型化合物及其抗肿瘤活性。一氧化氮供体可通过靶向释放一氧化氮,直接杀伤肿瘤细胞,提高肿瘤细胞对放化疗的敏感性,增强免疫系统作用,削弱肿瘤细胞侵袭能力,并抑制其转移,从而发挥抗肿瘤作用。The recent experimental researches on the anti-tumor mechanism of nitric oxide （NO） donors were reviewed. NO donor compounds and their anti-tumor activities were introduced classifiedly.By targeting release of NO, NO donors kill directly tumor ceils, strengthen the effect of immune system, to display anti-tumor activities. tumor ceils, enhance radioand ehemo-sensitivity of as well as inhibit tumor invasion and metastasis so as

关 键 词：一氧化氮供体 抗肿瘤活性 作用机制 实验研究 

分 类 号：R96[医药卫生—药理学] R730.5[医药卫生—药学]