胃肠道间质瘤53例临床病理分析  

Gastrointestinal stromal tumor:a clinical and pathological study of 53 cases

作　　者：蔡昶[1] 孟宪良[2] 李军[1] 夏燕[2] 张艮龙[1] 

机构地区：[1]安徽省宿州市立医院普外科,234000 [2]安徽省宿州市立医院病理科,234000

出　　处：《蚌埠医学院学报》2009年第10期911-913,共3页Journal of Bengbu Medical College

摘　　要：目的：探讨胃肠道间质瘤（gastrointestinal strornal tumor,GIST）的临床病理学特征。方法：回顾性分析经病理证实的53例GIST患者的临床和病理资料,并进行统计分析。结果：GIST较为少见,胃和小肠是好发部位,恶性程度与肿瘤大小有统计学意义（P〈0.01）,而与核分裂象、性别、年龄均无统计学意义（P〉0.05）;免疫表型CD117为84.91%,CD34为67.92%,vimentin为94.34%,平滑肌动蛋白（SMA）为60.38%,S-100蛋白为13.21%。根治性手术44例,姑息性切除术9例。随访11例,生存时间7-33个月。结论：GIST由于缺乏特征性临床表现,因此术前确诊率低,其确诊仍依赖病理结果。GIST均具有潜在恶性,术后需长期随访。CD117及CD34对于GIST的确诊有重要意义。Objective：To analyze the clinical and pathologic features of the gastrointestinal stromal tumor（GIST）.Methods：The clinical and pathological data of 53 patients of GIST were retrospectively analyzed.The expressions of CD117,CD34,vimentin,smooth muscle actin（SMA） and S-100 protein were detected with immunohistochemical staining.Results：The GIST was rarely seen;the stomach and the small intestine were its predilection sites;the size of the tumor was significantly correlated with the degree of malignancy（P〈0.01）.There was no correlation between malignancy and sex or age（P〉0.05）.The expressions rates of CD117,CD34,vimentin,SMA and S-100 protein were 84.91%,67.92%,94.34%,13.21% and 60.38%,respectively.Forty-four patients underwent radical excision,9 patients palliation excision and 11 patients were followed up.The post-operation live time was 7 to 33 months.Conclusions：The diagnosis of GIST is difficult,for it lacks clinical features.Final diagnosis still relies on pathological examination.The expressions of CD117 and CD34 protein are important predicting markers for final diagnosis of GIST.

关 键 词：胃肠肿瘤 胃肠道间质瘤 胃肠疾病/外科手术 病理学 临床 免疫组织化学 

分 类 号：R735[医药卫生—肿瘤]