HBV相关性肾炎与HBV基因变异的相关性  

Correlation of different hepatitis B virus gene mutations with the development of hepatitis B virus-associated glomerulonephritis

作　　者：李霜青[1] 安惠霞[1] 赵玉先[1] 姜国涛[2] 

机构地区：[1]哈尔滨医科大学附属第二医院肾内科,黑龙江省哈尔滨市150086 [2]天津市第五中心医院肾内科,天津市300450

出　　处：《世界华人消化杂志》2009年第23期2421-2425,共5页World Chinese Journal of Digestology

基　　金：黑龙江省自然科学基金资助项目;No080620~~

摘　　要：目的:探讨乙型肝炎病毒相关性肾炎(HBV-GN)易感性与HBV基因变异的关系.方法:选取HBV-GN患者19例为试验组,慢性HBV感染者22例为对照组,应用基因测序技术检测HBV血清C基因区、CP区基因位点的变异.结果:CP区中nt1727和nt1773位点试验组的变异率显著高于对照组(100%vs50.0%,47.4%vs13.6%,均P<0.05).nt1762/1764联合变异率在2组中的差别无统计学意义(P>0.05).C基因区中nt2011变异率试验组显著低于对照组(10.5%vs40.9%,P<0.05).nt2005、nt2201、nt2245和nt2290变异率在2组中的差别无统计学意义(P>0.05).结论:HBV-GN易感性可能与HBV的基因变异有关.AIM：To investigate the correlation of different hepatitis B virus gene mutations with the development of hepatitis B virus-associated glomerulonephritis（HBV-GN）. METHODS：Nineteen HBV-GN patients and 22 chronic hepatitis B（CHB）patients were included in the study.Gene mutations in the core gene coding region and core promoter/precore region of HBV were detected by complete genome sequencing. RESULTS：In the core promoter/precore region,the prevalences of the nt 1727 and nt 1773 mutations were significantly higher in HBV-GN patients than in CHB patients（100%vs 50.0%and 47.4%vs 13.6%,respectively;both P〈0.05）.No significant differences were noted in the prevalences of the nt 1762/1764 mutations between the two groups of patients（P〉0.05）.In the core gene coding region, the prevalence of the nt 2011 mutation was significantly lower in HBV-GN patients than in CHB patients（10.5%vs 40.9%,P〈0.05）.No significant differences were noted in the prevalences of the nt 2005,nt 2201,nt 2245 and nt 2290 mutations between the two groups of patients（P〉0.05）. CONCLUSION：Some hepatitis B virus gene mutations may be correlated with the development of HBV-GN.

关 键 词：乙型肝炎病毒 肾炎 基因变异 

分 类 号：R512.62[医药卫生—内科学] R692.31[医药卫生—临床医学]