Twist在涎腺腺样囊性癌中的表达及其临床意义  

Expression of Twist in adenoid cystic carcinoma of salivary glands and its clinicopathological significance

作　　者：沈末伦[1] 华成舸[2] 唐休发[2] 肖进[3] 

机构地区：[1]合肥市第二人民医院口腔颌面外科,安徽合肥230011 [2]四川大学华西口腔医院头颈肿瘤外科,四川成都610041 [3]温州医学院附属口腔医院口腔颌面外科,浙江温州325027

出　　处：《实用肿瘤杂志》2009年第5期441-445,共5页Journal of Practical Oncology

摘　　要：目的探讨转录因子Twist在涎腺腺样囊性癌中的表达水平及其与各临床病理因素的关系。方法采用免疫组化方法检测48例涎腺腺样囊性癌、18例多形性腺瘤和10正常腮腺组织中Twist蛋白的表达情况,分析Twist表达与腺样囊性癌临床病理因素的关系。结果Twist在涎腺腺样囊性癌组织中的表达水平明显高于多形性腺瘤和正常腮腺组织(P<0.05)。Twist表达与腺样囊性癌的病理分型、嗜神经侵袭、术后复发及远位转移有相关性(P<0.05)。结论Twist蛋白表达可能与涎腺腺样囊性癌的分化调节、嗜神经侵袭及远位转移有关。检测Twist的表达水平对判断腺样囊性癌患者的预后有一定的参考价值。Objective To investigate the expression of Twist in salivary adenoid cystic carcinoma（SACC） and its clinicopathological significance. Methods The expression of Twist was examined immunohistochemically in 48 cases of SACC,18 of pleomorphic adenoma and 10 of normal parotid gland.The relationship between Twist expression and clinicopathological factors was analyzed. Results Twist expression was significantly higher in SACC tissues compared with pleomorphic adenoma and normal parotid gland tissues （P〈0.05）.Twist expression levels in SACC were significantly associated with histological type,perineural invasion,postoperative recurrence and distant metastasis （all comparisons,P〈0.05）. Conclusions Twist expression may be associated with tumor cell differentiation,perineural invasion and metastasis of SACC.Twist expression is a potential prognostic factor for disease survival of SACC.

关 键 词：涎腺肿瘤 肿瘤侵润 肿瘤转移 蛋白Twist 预后 

分 类 号：R739.8[医药卫生—肿瘤]