淋巴细胞指数在评估成人急性淋巴细胞白血病预后中的意义  

Meaning of Lymphocyte Exponent Index in Evaluating the Prognosis after Adult Acute Lymphatic Leukemia’s Complete Remission

作　　者：汤孝优[1] 刘畅[1] 伍绍铮[1] 魏萍[1] 周红宇[1] 

机构地区：[1]解放军第169医院血液科,湖南衡阳421002

出　　处：《临床军医杂志》2009年第5期830-832,共3页Clinical Journal of Medical Officers

摘　　要：目的探索成人急性淋巴细胞白血病(ALL)首次完全缓解(CR)时骨髓淋巴细胞指数检测及其在评估预后中的价值。方法回顾性分析近5年初治的经1～2个疗程诱导治疗达到完全缓解的205例ALL,按照首次CR时骨髓中原始细胞比例及淋巴细胞指数将其分为4组:A、B组骨髓原始细胞比例<1%,A组淋巴细胞指数<30,B组≤30;C、D组原始细胞比例≤1%,C组淋巴细胞指数>30,D组≤30。分析原始细胞比例?淋巴细胞指数与持续缓解时间(CCR)的关系。C、D组作MRD检测。结果A组原始细胞及淋巴细胞指数高于B组,CCR短于B组。C组与D组原始细胞比例相近,但C组淋巴细胞指数高,MRD高于D组,CCR时间短。C组CCR与B组无差异。结论CR后骨髓淋巴细胞指数与急性淋巴细胞白血病患者的CCR密切相关,它较原始细胞比例更准确?全面反映体内白血病细胞残留水平。淋巴细胞指数的检测有助于判断预后及指导今后的治疗。Objective To investigate the value of lymphocyte exponent after adult acute lymphatic leukemia’s first complete remission（CR）.Methods 205 cases who have been diagnosed in the past five years and gotten complete remission after one or two induction therapy,allocate to A,B,C,D group： marrow primary cells of A and B groups are less than 1%.Lymphocyte exponent of A is more than 30 and B is less than 30. marrow primary cells of C and D groups are 1% or less than 1%,lymphocyte exponent of C is more than 30,and D is less than 30.Comparing all groups’ primary cells rate,lymphocyte exponent and continuous complete remission（CCR）.MRD test is performed in group C and D.Results The primary cells and lymphocyte exponent of A group are more than B group,CCR is shorter than B. The primary cells rate of C and D is similar,but lymphocyte exponent of C is more than D,CCR is shorter than D,Postive of MRD is higher than D. There’s no difference between B and C’s CCR.Conclusion After first CR,the marrow lymphocyte exponent will affect CCR of acute lymphatic leukemia patients. It is better than primary cells to react the residual level of leukemia cells,what’s more,it is useful for therapy.

关 键 词：急性淋巴细胞白血病 淋巴细胞指数 持续完全缓解 

分 类 号：R733.7[医药卫生—肿瘤]