莫诺苷对大鼠局灶性脑缺血再灌注模型脑梗死体积的影响  

Effect of Morroniside on Cerebral Infarction Volume in Focal Cerebral Ischemia-reperfusion Rats

作　　者：刘秀平[1] 许栋明[3] 王文[2] 王烈群[1] 张丽[2] 艾厚喜[2] 李林[2] 

机构地区：[1]内蒙古医学院,内蒙古呼和浩特市010059 [2]首都医科大学宣武医院,北京市100053 [3]科技部火炬高技术产业开发中心,北京市100038

出　　处：《中国康复理论与实践》2009年第10期913-915,共3页Chinese Journal of Rehabilitation Theory and Practice

基　　金：“重大新药创制”科技重大专项(2009ZX09103-366);国家自然科学基金项目(30740053);北京市自然科学基金项目(7062031)

摘　　要：目的观察莫诺苷对大脑中动脉阻塞法(MACO)致脑缺血再灌注模型大鼠脑梗死体积的影响。方法用线栓法制备局灶性脑缺血再灌注大鼠模型,缺血30min,再灌注7d。采用2,3,5-氯化三苯基四氮唑(TTC)染色,检测大鼠的脑梗死体积。结果与假手术组相比,模型组及给药组出现明显梗死灶;与模型组相比,莫诺苷(90mg/kg,270mg/kg)脑梗死体积显著减少,维生素E(35mg/kg)组脑梗死体积未出现明显改变。结论莫诺苷可减少局灶性脑缺血再灌注大鼠脑梗死体积,对脑缺血再灌注损伤有保护作用。Objective To observe the effect of morroniside on cerebral infarction volume in focal cerebral ischemia-reperfusion rat model.Methods The animal model was induced by occlusion of middle cerebral artery with suture embolus,ischemia for 30 minutes,and reperfusion for 7 days.The infarction volume was measured by 2,3,5-triphenyltetrazolium chloride（TTC） staining technique.Results Compared with sham operation group,the cerebral infarction volume ratios increased obviously in model group and in the drug-treated（90 mg/kg,270 mg/kg）groups.Compared with model group,the cerebral infarction volume ratios decreased obviously in the morroniside-treated（90 mg/kg,270 mg/kg）group,while the cerebral infarction volume ratios in vitamin E-treated（35 mg/kg）group didn＇t change.Conclusion Morroniside may decrease the cerebral infarction volume after cerebral ischemia-reperfusion.It possesses protective effect against cerebral ischemia-reperfusion injury.

关 键 词：莫诺苷 脑缺血再灌注 脑梗死体积 

分 类 号：R743.3[医药卫生—神经病学与精神病学]