急性白血病继发骨髓纤维化34例骨髓的活检  

A report of acute leukemia with reticulin myelofibrosis in 34 cases

作　　者：张启国[1] 浦权[1] 杨梅如[1] 陶英[1] 刘薏芝[1] 张子祥[1] 

机构地区：[1]上海市第六人民医院血液科,200233

出　　处：《新医学》1998年第11期577-578,共2页Journal of New Medicine

摘　　要：目的 :评估骨髓活检在急性白血病继发骨髓纤维化时的诊断价值。方法 :对比分析 34例急性白血病继发骨髓纤维化的骨髓活检切片与涂片增生度 ,动态观察 10例急性粒细胞白血病化疗过程中网硬蛋白纤维含量变化。结果 :网硬蛋白纤维可致白血病骨髓涂片假性增生减低 ,骨髓活检切片能起修正作用。伴骨髓纤维化的早期白血病骨髓切片较涂片更早作出诊断。网硬蛋白纤维含量的变化与白血病化疗疗效有关。结论 :骨髓活检切片对涂片起补充修正作用 ,诊断急性白血病须把二者结合起来分析。Objective:To explore the value of trephine biopsy in diagnosing acute leukemia with reticulin myelofibrosis.Methods:The cellularity of trephine biopsy was compared to that of aspiration in 34 cases with acute leukemia.The level of reticulin fiber was also monitered during chemical therapy in 10 AML.Results:Reticulin myelofiberosis led to pseudohypoplastic leukemia shown in bone marrow smear,which could be corrected by trephine biopsy.Trephine biopsy showed the change earlier than aspiration in the early leukemia with reticulin myelofibrosis.The level of reticulin fiber was related to chemical therapeutical effects.Conclusion:The diagnose of acute leukemia with reticulin myelofibrosis should combine the bone marrow aspiration with trephine biopsy.

关 键 词：白血病 急性 骨髓纤维化 骨髓活检 继发性 

分 类 号：R733.71[医药卫生—肿瘤]