阿霉素纳米微粒经动脉给药对兔肝肿瘤的疗效观察  

Therapeutic Effects of Adriamycin-Loaded Nanoparticles Administered Via Hepatic Artery Against Rabbit Hepatoma

作　　者：杨华[1] 易军[1] 姚青[1] 陈江浩[1] 王岭[1] 凌瑞[1] 

机构地区：[1]第四军医大学西京医院血管外科,陕西西安710033

出　　处：《医学信息》2009年第11期2427-2430,共4页Journal of Medical Information

摘　　要：目的观察阿霉素纳米微粒经动脉给药对兔肝肿瘤的疗效。方法将阿霉素纳米微粒(小粒径脂质体与毫微粒)与碘油制成乳剂,建立兔肝VX-2移植癌改良模型并随机分为六组,经肝动脉分别注入生理盐水(NS)、碘油(Lipi)、游离丝裂霉素(ADM,2mg/kg)、游离阿霉素加空白纳米微粒(ADM+NP,2mg/kg)、阿霉素纳米微粒组(NADM,2mg/kg)与阿霉素纳米微粒-碘油乳剂(Lip-NADM,2mg/kg)。结果经Lip-NADM治疗的兔生存期显著延长(P<0.01),与其它各组相比对肿瘤生长的抑制更为明显(P<0.01),肿瘤坏死更广泛,更彻底。结论与其它各组相比,Lip-NADM经动脉给药具有更好的疗效。Objective To observe the therapeutic effects against rabbit hepatoma with adriamycin-loaded nanoparticles-lipiodol （Lip- NADM） administered via hepatic artery. Methods Lip-NADM was prepared by the interfacial polymerization method. Normal saline, lipiodol, free adriamycin （ADM, 2mg/kg）, adriamycin plus blank nanoparticle （ADM＋NP, 2mg/kg）, adriamycin -loaded nanoparticles （NADM, 2mg/kg）, and Lip-NADM were injected respectively via the hepatic artery into six groups of rabbit VX-2 liver tumor model. Results The survival time was prolonged in animals treated with Lip-NADM significantly （P〈0,01）; the tumor growth inhibition was more significant （P〈0.01） and necrosis more extensive in comparison with animals received other groups. Conclusion Hepatic arterial infusion of Lip-NADM was more effective than all other groups.

关 键 词：肝肿瘤 阿霉素 纳米微粒-碘油乳剂 

分 类 号：R737.14[医药卫生—肿瘤] R944.9[医药卫生—临床医学]